{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(10)"],"submitter":["Lei Y"],"pubmed_abstract":["B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is overexpressed in various cancer types. We found that <i>Bmi-1</i> mRNA levels were elevated in nasopharyngeal carcinoma (NPC) cell lines. In immunohistochemical analyses, high Bmi-1 levels were observed in not only 5 of 38 non-cancerous nasopharyngeal squamous epithelial biopsies, but also in 66 of 98 NPC specimens (67.3%). High Bmi-1 levels were detected more frequently in T3-T4, N2-N3 and stage III-IV NPC biopsies than in T1-T2, N0-N1 and stage I-II NPC samples, indicating that Bmi-1 is upregulated in advanced NPC. In 5-8F and SUNE1 NPC cells, stable depletion of Bmi-1 using lentiviral RNA interference greatly suppressed cell proliferation, induced G1-phase cell cycle arrest, reduced cell stemness and suppressed "],"journal":["Aging"],"pagination":["4391-4410"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10258013"],"repository":["biostudies-literature"],"pubmed_title":["Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating <i>Bmi-1</i>."],"pmcid":["PMC10258013"],"pubmed_authors":["Zhou ZH","He DH","Xia JW","Xiao SJ","Lin XL","Chen ML","Wang SC","Zhou Y","Li XF","Dai GQ","Cong JG","Li YC","Zhang XK","Li QW","Lei Y","Xie HT","Huang SH","Wu AB","Xiao D","Yang S","Jia JS","Shen HF","Lin TY"],"additional_accession":[]},"is_claimable":false,"name":"Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating <i>Bmi-1</i>.","description":"B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is overexpressed in various cancer types. We found that <i>Bmi-1</i> mRNA levels were elevated in nasopharyngeal carcinoma (NPC) cell lines. In immunohistochemical analyses, high Bmi-1 levels were observed in not only 5 of 38 non-cancerous nasopharyngeal squamous epithelial biopsies, but also in 66 of 98 NPC specimens (67.3%). High Bmi-1 levels were detected more frequently in T3-T4, N2-N3 and stage III-IV NPC biopsies than in T1-T2, N0-N1 and stage I-II NPC samples, indicating that Bmi-1 is upregulated in advanced NPC. In 5-8F and SUNE1 NPC cells, stable depletion of Bmi-1 using lentiviral RNA interference greatly suppressed cell proliferation, induced G1-phase cell cycle arrest, reduced cell stemness and suppressed ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-06-01T00:25:57.724Z","creation":"2025-06-01T00:25:57.724Z"},"accession":"S-EPMC10258013","cross_references":{"pubmed":["37219449"],"doi":["10.18632/aging.204742"]}}