{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paschold L"],"funding":["Deutsche Krebshilfe","Martin-Luther-Universität Halle-Wittenberg"],"pagination":["9516"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10258752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["We set out to gain insight into peripheral blood B and T cell repertoires from 120 infants of the LoewenKIDS birth cohort to investigate potential determinants of early life respiratory infections. Low antigen-dependent somatic hypermutation of B cell repertoires, as well as low T and B cell repertoire clonality, high diversity, and high richness especially in public T cell clonotypes reflected the immunological naivety at 12 months of age when high thymic and bone marrow output are associated with relatively few prior antigen encounters. Infants with inadequately low T cell repertoire diversity or high clonality showed higher numbers of acute respiratory infections over the first 4 years of life. No correlation of T or B cell repertoire metrics with other parameters such as sex, birth mod"],"journal":["Scientific reports"],"pubmed_title":["T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort."],"pmcid":["PMC10258752"],"funding_grant_id":["70114663"],"pubmed_authors":["Riese P","Trittel S","Schultheiß C","Mikolajczyk R","Langer S","Strowig T","Gottschick C","Paschold L","Eberl W","Dressler F","Hubner J","Guzman CA","Binder M","Diexer S","Purschke O","Aksentijevich I","Klee B","Haase R"],"additional_accession":[]},"is_claimable":false,"name":"T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort.","description":"We set out to gain insight into peripheral blood B and T cell repertoires from 120 infants of the LoewenKIDS birth cohort to investigate potential determinants of early life respiratory infections. Low antigen-dependent somatic hypermutation of B cell repertoires, as well as low T and B cell repertoire clonality, high diversity, and high richness especially in public T cell clonotypes reflected the immunological naivety at 12 months of age when high thymic and bone marrow output are associated with relatively few prior antigen encounters. Infants with inadequately low T cell repertoire diversity or high clonality showed higher numbers of acute respiratory infections over the first 4 years of life. No correlation of T or B cell repertoire metrics with other parameters such as sex, birth mod","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-05-29T01:14:39.668Z","creation":"2024-12-03T19:33:25.488Z"},"accession":"S-EPMC10258752","cross_references":{"pubmed":["37308563"],"doi":["10.1038/s41598-023-36144-x"]}}