biostudies-literaturePaschold LDeutsche KrebshilfeMartin-Luther-Universität Halle-Wittenberg9516https://www.ebi.ac.uk/biostudies/studies/S-EPMC10258752biostudies-literatureUnknown13(1)We set out to gain insight into peripheral blood B and T cell repertoires from 120 infants of the LoewenKIDS birth cohort to investigate potential determinants of early life respiratory infections. Low antigen-dependent somatic hypermutation of B cell repertoires, as well as low T and B cell repertoire clonality, high diversity, and high richness especially in public T cell clonotypes reflected the immunological naivety at 12 months of age when high thymic and bone marrow output are associated with relatively few prior antigen encounters. Infants with inadequately low T cell repertoire diversity or high clonality showed higher numbers of acute respiratory infections over the first 4 years of life. No correlation of T or B cell repertoire metrics with other parameters such as sex, birth modScientific reportsT cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort.PMC1025875270114663Riese PTrittel SSchultheiß CMikolajczyk RLanger SStrowig TGottschick CPaschold LEberl WDressler FHubner JGuzman CABinder MDiexer SPurschke OAksentijevich IKlee BHaase RfalseT cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort.We set out to gain insight into peripheral blood B and T cell repertoires from 120 infants of the LoewenKIDS birth cohort to investigate potential determinants of early life respiratory infections. Low antigen-dependent somatic hypermutation of B cell repertoires, as well as low T and B cell repertoire clonality, high diversity, and high richness especially in public T cell clonotypes reflected the immunological naivety at 12 months of age when high thymic and bone marrow output are associated with relatively few prior antigen encounters. Infants with inadequately low T cell repertoire diversity or high clonality showed higher numbers of acute respiratory infections over the first 4 years of life. No correlation of T or B cell repertoire metrics with other parameters such as sex, birth mod2023-01-01T00:00:00Z2023 Jun2026-05-29T01:14:39.668Z2024-12-03T19:33:25.488ZS-EPMC102587523730856310.1038/s41598-023-36144-x