{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meng FZ"],"funding":["The National Key Research and Development Program"],"pagination":["e1011011"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10270592"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(6)"],"pubmed_abstract":["Isoprothiolane (IPT) resistance has emerged in Magnaporthe oryzae, due to the long-term usage of IPT to control rice blast in China, yet the mechanisms of the resistance remain largely unknown. Through IPT adaptation on PDA medium, we obtained a variety of IPT-resistant mutants. Based on their EC50 values to IPT, the resistant mutants were mainly divided into three distinct categories, i.e., low resistance (LR, 6.5 ≤ EC50 < 13.0 μg/mL), moderate resistance 1 (MR-1, 13.0 ≤ EC50 < 25.0 μg/mL), and moderate resistance 2 (MR-2, 25.0 ≤ EC50 < 35.0 μg/mL). Molecular analysis of MoIRR (Magnaporthe oryzae isoprothiolane resistance related) gene demonstrated that it was associated only with the moderate resistance in MR-2 mutants, indicating that other mechanisms were associated with resistance in "],"journal":["PLoS pathogens"],"pubmed_title":["The velvet family proteins mediate low resistance to isoprothiolane in Magnaporthe oryzae."],"pmcid":["PMC10270592"],"funding_grant_id":["No. 2016YFD0300700"],"pubmed_authors":["Meng FZ","Wang ZQ","Yin LF","Luo M","Yin WX","Luo CX","Wei WK","Schnabel G"],"additional_accession":[]},"is_claimable":false,"name":"The velvet family proteins mediate low resistance to isoprothiolane in Magnaporthe oryzae.","description":"Isoprothiolane (IPT) resistance has emerged in Magnaporthe oryzae, due to the long-term usage of IPT to control rice blast in China, yet the mechanisms of the resistance remain largely unknown. Through IPT adaptation on PDA medium, we obtained a variety of IPT-resistant mutants. Based on their EC50 values to IPT, the resistant mutants were mainly divided into three distinct categories, i.e., low resistance (LR, 6.5 ≤ EC50 < 13.0 μg/mL), moderate resistance 1 (MR-1, 13.0 ≤ EC50 < 25.0 μg/mL), and moderate resistance 2 (MR-2, 25.0 ≤ EC50 < 35.0 μg/mL). Molecular analysis of MoIRR (Magnaporthe oryzae isoprothiolane resistance related) gene demonstrated that it was associated only with the moderate resistance in MR-2 mutants, indicating that other mechanisms were associated with resistance in ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-18T20:35:29.592Z","creation":"2025-04-07T08:29:15.713Z"},"accession":"S-EPMC10270592","cross_references":{"pubmed":["37276223"],"doi":["10.1371/journal.ppat.1011011"]}}