{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Houston J"],"funding":["National Research Foundation of Korea","National Institutes of Health","National Institute of General Medical Sciences","Ludwig Institute for Cancer Research","NIGMS NIH HHS","National Science Foundation"],"pagination":["2291-2299.e10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10270731"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(11)"],"pubmed_abstract":["During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle microtubules.<sup>1</sup><sup>,</sup><sup>2</sup> Kinetochores also function as signaling hubs directing mitotic progression by recruiting and controlling the fate of the anaphase promoting complex/cyclosome (APC/C) activator CDC-20.<sup>3</sup><sup>,</sup><sup>4</sup><sup>,</sup><sup>5</sup> Kinetochores either incorporate CDC-20 into checkpoint complexes that inhibit the APC/C or dephosphorylate CDC-20, which allows it to interact with and activate the APC/C.<sup>4</sup><sup>,</sup><sup>6</sup> The importance of these two CDC-20 fates likely depends on the biological context. In human somatic cells, the major mechanism controlling mitotic progression is the spindle checkpoint. By contrast, progression th"],"journal":["Current biology : CB"],"pubmed_title":["BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses."],"pmcid":["PMC10270731"],"funding_grant_id":["1650112","R01 GM074215","NRF-2020RC1C1008596","R35 GM144121","R01 GM074207"],"pubmed_authors":["Kim T","Oegema K","Gomez-Cavazos JS","Deep A","Houston J","Desai A","Lara-Gonzalez P","Ohta M","Corbett KD"],"additional_accession":[]},"is_claimable":false,"name":"BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.","description":"During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle microtubules.<sup>1</sup><sup>,</sup><sup>2</sup> Kinetochores also function as signaling hubs directing mitotic progression by recruiting and controlling the fate of the anaphase promoting complex/cyclosome (APC/C) activator CDC-20.<sup>3</sup><sup>,</sup><sup>4</sup><sup>,</sup><sup>5</sup> Kinetochores either incorporate CDC-20 into checkpoint complexes that inhibit the APC/C or dephosphorylate CDC-20, which allows it to interact with and activate the APC/C.<sup>4</sup><sup>,</sup><sup>6</sup> The importance of these two CDC-20 fates likely depends on the biological context. In human somatic cells, the major mechanism controlling mitotic progression is the spindle checkpoint. By contrast, progression th","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-04-08T19:48:24.322Z","creation":"2026-04-08T14:33:07.942Z"},"accession":"S-EPMC10270731","cross_references":{"pubmed":["37137308"],"doi":["10.1016/j.cub.2023.04.021"]}}