biostudies-literatureChesworth RWestern Sydney UniversityNational Health and Medical Research CouncilRebecca L. Cooper Medical Research FoundationDementia Australia Research Foundation1531-1546https://www.ebi.ac.uk/biostudies/studies/S-EPMC10271887biostudies-literatureUnknown240(7)<h4>Background</h4>Individuals with schizophrenia have high rates of comorbid substance use problems. One potential explanation for this comorbidity is similar neuropathophysiology in substance use and schizophrenia, which may arise from shared genetic risk factors between the two disorders. Here we investigated if genetic risk for schizophrenia could affect drug reward and reinforcement for cocaine in an established mouse model of genetic risk for schizophrenia, the neuregulin 1 transmembrane domain heterozygous (Nrg1 TM HET) mouse.<h4>Methods</h4>We examined drug-induced locomotor sensitization and conditioned place preference for several cocaine doses (5, 10, 20, 30 mg/kg) in male adult Nrg1 TM HET and wild-type-like (WT) littermates. We also investigated intravenous self-administrationPsychopharmacologyImpaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk.PMC10271887Project Grant 2022110201211417891095215PG2020883Visini GKarl TChesworth RfalseImpaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk.<h4>Background</h4>Individuals with schizophrenia have high rates of comorbid substance use problems. One potential explanation for this comorbidity is similar neuropathophysiology in substance use and schizophrenia, which may arise from shared genetic risk factors between the two disorders. Here we investigated if genetic risk for schizophrenia could affect drug reward and reinforcement for cocaine in an established mouse model of genetic risk for schizophrenia, the neuregulin 1 transmembrane domain heterozygous (Nrg1 TM HET) mouse.<h4>Methods</h4>We examined drug-induced locomotor sensitization and conditioned place preference for several cocaine doses (5, 10, 20, 30 mg/kg) in male adult Nrg1 TM HET and wild-type-like (WT) littermates. We also investigated intravenous self-administration2023-01-01T00:00:00Z2023 Jul2025-04-18T20:35:47.865Z2025-02-19T00:50:04.415ZS-EPMC102718873723381410.1007/s00213-023-06386-8