{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(7)"],"submitter":["Korn S"],"funding":["Amgen, Thousand Oaks, CA","AstraZeneca, Wilmington, DE"],"pubmed_abstract":["<h4>Introduction</h4>Randomized controlled trials (RCTs) of biologics in patients with severe, uncontrolled asthma have shown differential results by baseline blood eosinophil count (BEC). In the absence of head-to-head trials, we describe the effects of biologics on annualized asthma exacerbation rate (AAER) by baseline BEC in placebo-controlled RCTs. Exacerbations associated with hospitalization or an emergency room visit, pre-bronchodilator forced expiratory volume in 1 s, Asthma Control Questionnaire score, and Asthma Quality of Life Questionnaire score were also summarized.<h4>Methods</h4>MEDLINE (via PubMed) was searched for RCTs of biologics in patients with severe, uncontrolled asthma and with AAER reduction as a primary or secondary endpoint. AAER ratios and change from baseline i"],"journal":["Advances in therapy"],"pagination":["2944-2964"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10272272"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of Biologics in Severe, Uncontrolled Asthma Stratified by Blood Eosinophil Count: A Systematic Review."],"pmcid":["PMC10272272"],"pubmed_authors":["Simpson LJ","Ambrose CS","Llanos JP","Korn S","Cook B"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of Biologics in Severe, Uncontrolled Asthma Stratified by Blood Eosinophil Count: A Systematic Review.","description":"<h4>Introduction</h4>Randomized controlled trials (RCTs) of biologics in patients with severe, uncontrolled asthma have shown differential results by baseline blood eosinophil count (BEC). In the absence of head-to-head trials, we describe the effects of biologics on annualized asthma exacerbation rate (AAER) by baseline BEC in placebo-controlled RCTs. Exacerbations associated with hospitalization or an emergency room visit, pre-bronchodilator forced expiratory volume in 1 s, Asthma Control Questionnaire score, and Asthma Quality of Life Questionnaire score were also summarized.<h4>Methods</h4>MEDLINE (via PubMed) was searched for RCTs of biologics in patients with severe, uncontrolled asthma and with AAER reduction as a primary or secondary endpoint. AAER ratios and change from baseline i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-07-14T19:19:32.168Z","creation":"2025-02-19T00:50:03.4Z"},"accession":"S-EPMC10272272","cross_references":{"pubmed":["37233876"],"doi":["10.1007/s12325-023-02514-0"]}}