biostudies-literatureUnknown9(5)Williams SEMedical Research FoundationEuropean Research CouncilMRF_Royal SocietyWellcome TrustBiotechnology and Biological Sciences Research CouncilThe deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria is of broad interest in ecology and could also underpin applied drug discovery, specifically in the area of antimicrobials. Here, we isolate a new strain of <i>Streptomyces</i> from the tissue of the deep-sea sponge <i>Polymastia corticata</i> collected at a depth of 1869 m from the Gramberg Seamount in the Atlantic Ocean. This strain, which was given the initial designation A15ISP2-DRY2<sup>T</sup>, has a genome size of 9.29 Mb with a G+C content of 70.83 mol%. Phylogenomics determined that A15ISP2-DRY2<sup>T</sup> represents a novel species within the genus <i>Streptomyces</i> as part of the <i>Streptomyces aurantiacus</i> clade. Microbial genomicshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC10272871biostudies-literatureDiscovery and biosynthetic assessment of '<i>Streptomyces ortus'</i> sp. nov. isolated from a deep-sea sponge.PMC10272871BB/M025624/1BB/T001968/1MRF-131-0005-RG-RACE-C0853BB/W013959/1URF\R\201024278705Williams TACurnow PRace PRStach JEMBest EWilliams SEBack CRMantell JfalseDiscovery and biosynthetic assessment of '<i>Streptomyces ortus'</i> sp. nov. isolated from a deep-sea sponge.The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria is of broad interest in ecology and could also underpin applied drug discovery, specifically in the area of antimicrobials. Here, we isolate a new strain of <i>Streptomyces</i> from the tissue of the deep-sea sponge <i>Polymastia corticata</i> collected at a depth of 1869 m from the Gramberg Seamount in the Atlantic Ocean. This strain, which was given the initial designation A15ISP2-DRY2<sup>T</sup>, has a genome size of 9.29 Mb with a G+C content of 70.83 mol%. Phylogenomics determined that A15ISP2-DRY2<sup>T</sup> represents a novel species within the genus <i>Streptomyces</i> as part of the <i>Streptomyces aurantiacus</i> clade. 2023-01-01T00:00:00Z2023 May2026-04-29T02:25:44.86Z2025-02-19T04:01:45.559ZS-EPMC102728713716695510.1099/mgen.0.000996