{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(5)"],"submitter":["Hetland MAK"],"funding":["Western Norway Regional Health Authority","Trond Mohn stiftelse"],"pubmed_abstract":["<i>Klebsiella pneumoniae</i> sequence type (ST) 17 is a global problem clone that causes multidrug-resistant (MDR) hospital infections worldwide. In 2008-2009, an outbreak of MDR ST17 occurred at a neonatal intensive care unit (NICU) in Stavanger, Norway. Fifty-seven children were colonized. We observed intestinal persistence of ST17 in all of the children for up to two years after hospital discharge. Here, we investigated the within-host evolution of ST17 in 45 of those children during long-term colonization and compared the outbreak with 254 global strains. Ninety-two outbreak-related isolates were whole-genome sequenced. They had capsule locus KL25, O locus O5 and carried yersiniabactin. During within-host colonization ST17 remained stable with few single nucleotide polymorphisms, no ac"],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10272876"],"repository":["biostudies-literature"],"pubmed_title":["Within-patient and global evolutionary dynamics of <i>Klebsiella pneumoniae</i> ST17."],"pmcid":["PMC10272876"],"funding_grant_id":["F-12508","TMS2019TMT03"],"pubmed_authors":["Rettedal SI","Kaspersen H","Lohr IH","Bakksjo RJ","Hetland MAK","Holt KE","Bernhoff E","Sundsfjord A","Hawkey J"],"additional_accession":[]},"is_claimable":false,"name":"Within-patient and global evolutionary dynamics of <i>Klebsiella pneumoniae</i> ST17.","description":"<i>Klebsiella pneumoniae</i> sequence type (ST) 17 is a global problem clone that causes multidrug-resistant (MDR) hospital infections worldwide. In 2008-2009, an outbreak of MDR ST17 occurred at a neonatal intensive care unit (NICU) in Stavanger, Norway. Fifty-seven children were colonized. We observed intestinal persistence of ST17 in all of the children for up to two years after hospital discharge. Here, we investigated the within-host evolution of ST17 in 45 of those children during long-term colonization and compared the outbreak with 254 global strains. Ninety-two outbreak-related isolates were whole-genome sequenced. They had capsule locus KL25, O locus O5 and carried yersiniabactin. During within-host colonization ST17 remained stable with few single nucleotide polymorphisms, no ac","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-04-29T02:31:04.854Z","creation":"2025-02-19T04:01:35.852Z"},"accession":"S-EPMC10272876","cross_references":{"pubmed":["37200066"],"doi":["10.1099/mgen.0.001005"]}}