{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ishii T"],"funding":["NIDCR NIH HHS","NIA NIH HHS","Osteo Science Foundation","National Institute of Dental and Craniofacial Research","NCI NIH HHS","National Institute on Aging"],"pagination":["1750-1756"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10273054"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(12)"],"pubmed_abstract":["Bone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti-coupling factors. Amongst formally known anti-coupling factors, Semaphorin 4D (Sema4D), produced by osteoclasts, plays a key role in downmodulating osteoblastogenesis. Sema4D is produced in both membrane-bound and soluble forms; however, the mechanism responsible for producing sSema4D from osteoclasts is unknown. Sema4D, TACE and MT1-MMP are all expressed on the surface of RANKL-primed osteoclast precursors. However, only Sema4D and TACE were colocalized, not Sema4D and MT1-MMP. When TACE and MT1-MMP were either chemically inhibited or suppressed by siRNA, TACE was found to be more engaged in shedding Sema4D. Anti-TACE-mAb inhibited sSema4D releas"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis."],"pmcid":["PMC10273054"],"funding_grant_id":["DE027851","R01 DE029709","R56 AG064003","R15 CA249788","DE028715","R21 DE028715","R15 DE027851","DE029709","AG064003","333466","R01 AG064003"],"pubmed_authors":["Wisitrasameewong W","Kanzaki H","Albassam A","Pierrelus R","Kawai T","Shindo S","Movila A","Kandalam U","Heidari A","Kim JY","Ruiz-Torruella M","Minond D","Ishii T","Nakamura S"],"additional_accession":[]},"is_claimable":false,"name":"Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis.","description":"Bone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti-coupling factors. Amongst formally known anti-coupling factors, Semaphorin 4D (Sema4D), produced by osteoclasts, plays a key role in downmodulating osteoblastogenesis. Sema4D is produced in both membrane-bound and soluble forms; however, the mechanism responsible for producing sSema4D from osteoclasts is unknown. Sema4D, TACE and MT1-MMP are all expressed on the surface of RANKL-primed osteoclast precursors. However, only Sema4D and TACE were colocalized, not Sema4D and MT1-MMP. When TACE and MT1-MMP were either chemically inhibited or suppressed by siRNA, TACE was found to be more engaged in shedding Sema4D. Anti-TACE-mAb inhibited sSema4D releas","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-18T20:36:38.178Z","creation":"2025-04-07T08:34:37.018Z"},"accession":"S-EPMC10273054","cross_references":{"pubmed":["37170687"],"doi":["10.1111/jcmm.17416"]}}