biostudies-literatureSun SBrain Tumor Precision Diagnosis and Treatment and Translational Medicine Innovation Unit of Chinese Academy of Medical SciencesBeijing Municipal Health Commission FundBeijing Hospitals Authority Youth Programme551https://www.ebi.ac.uk/biostudies/studies/S-EPMC10273567biostudies-literatureUnknown23(1)Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequencing (RNA-seq) data (n = 1022 cases) and whole-exome sequencing (WES) data (n = 286 cases) were used to characterize the PTRF expression features. Gene ontology (GO) functional enrichment analysis was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed distBMC cancerMolecular and clinical characterization of PTRF in glioma via 1,022 samples.PMC102735672019-I2M-5-021QML2023050711000023T000002044300-5Liu YZhang KNCao ZSun SJiang TYang CHuang RZhao ZWang KfalseMolecular and clinical characterization of PTRF in glioma via 1,022 samples.Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequencing (RNA-seq) data (n = 1022 cases) and whole-exome sequencing (WES) data (n = 286 cases) were used to characterize the PTRF expression features. Gene ontology (GO) functional enrichment analysis was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed dist2023-01-01T00:00:00Z2023 Jun2025-04-18T20:34:27.501Z2025-02-19T00:50:14.896ZS-EPMC102735673732240810.1186/s12885-023-11001-2