{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["54(1-2)"],"submitter":["Mende CW"],"pubmed_abstract":["<h4>Background</h4>Diabetic kidney disease (DKD) is a common disorder with multiple serious clinical implications, including an increased risk of end-stage kidney disease (ESKD), cardiovascular complications, heart failure, onset or worsening of hypertension, and premature death. Patients with DKD frequently require dialysis or kidney transplantation to manage their ESKD.<h4>Summary</h4>Upregulation of the renin-angiotensin-aldosterone system is an important contributor to kidney disease progression, as highlighted by the results of trials evaluating angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with albuminuria. Increasing evidence suggests the existence of a multidirectional network that involves aldosterone, the mineralocorticoid receptor (MR), a"],"journal":["American journal of nephrology"],"pagination":["50-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10273909"],"repository":["biostudies-literature"],"pubmed_title":["Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists."],"pmcid":["PMC10273909"],"pubmed_authors":["Mende CW","Samarakoon R","Higgins PJ"],"additional_accession":[]},"is_claimable":false,"name":"Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists.","description":"<h4>Background</h4>Diabetic kidney disease (DKD) is a common disorder with multiple serious clinical implications, including an increased risk of end-stage kidney disease (ESKD), cardiovascular complications, heart failure, onset or worsening of hypertension, and premature death. Patients with DKD frequently require dialysis or kidney transplantation to manage their ESKD.<h4>Summary</h4>Upregulation of the renin-angiotensin-aldosterone system is an important contributor to kidney disease progression, as highlighted by the results of trials evaluating angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with albuminuria. Increasing evidence suggests the existence of a multidirectional network that involves aldosterone, the mineralocorticoid receptor (MR), a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-13T14:27:01.732Z","creation":"2025-04-03T22:51:09.731Z"},"accession":"S-EPMC10273909","cross_references":{"pubmed":["36682353"],"doi":["10.1159/000528783"]}}