biostudies-literatureUnknownProkhorenko MANINDS NIH HHSNIH HHSCentral sensitization is a critical step in chronic neuropathic pain formation following acute nerve injury. Central sensitization is defined by nociceptive and somatosensory circuitry changes in the spinal cord leading to dysfunction of antinociceptive gamma-aminobutyric acid (GABA)ergic cells (Li et al., 2019), amplification of ascending nociceptive signals, and hypersensitivity (Woolf, 2011). Astrocytes are key mediators of the neurocircuitry changes that underlie central sensitization and neuropathic pain, and astrocytes respond to and regulate neuronal function through complex Ca²⁺ signaling mechanisms. Clear definition of the astrocyte Ca²⁺ signaling mechanisms involved in central sensitization may lead to new therapeutic targets for treatment of chronic neuropabioRxiv : the preprint server for biology2023.06.08.544231https://www.ebi.ac.uk/biostudies/studies/S-EPMC10274864biostudies-literatureAstrocyte store-operated calcium entry is required for centrally mediated neuropathic pain.PMC10274864P40 OD018537R21 NS121821Smyth JTProkhorenko MAfalseAstrocyte store-operated calcium entry is required for centrally mediated neuropathic pain.Central sensitization is a critical step in chronic neuropathic pain formation following acute nerve injury. Central sensitization is defined by nociceptive and somatosensory circuitry changes in the spinal cord leading to dysfunction of antinociceptive gamma-aminobutyric acid (GABA)ergic cells (Li et al., 2019), amplification of ascending nociceptive signals, and hypersensitivity (Woolf, 2011). Astrocytes are key mediators of the neurocircuitry changes that underlie central sensitization and neuropathic pain, and astrocytes respond to and regulate neuronal function through complex Ca²⁺ signaling mechanisms. Clear definition of the astrocyte Ca²⁺ signaling mechanisms involved in central sensitization may lead to new therapeutic targets for treatment of chronic neuropa2023-01-01T00:00:00Z2023 Jun2026-04-08T05:48:26.247Z2026-04-07T22:40:20.711ZS-EPMC102748643733323010.1101/2023.06.08.544231