biostudies-literatureUnknownMaier ASwiss State Secretariat for Education, Research and InnovationNational Institute of Diabetes and Digestive and Kidney DiseasesGerman Federal Ministry of Education and ResearchGerman Excellence InitiativeIBM and Ian Lawson van Toch FundSpanish State Research AgencyHorizon Europe project Repo4EUNatural Sciences Research CouncilDeutsche ForschungsgemeinschaftEuropean Research CouncilEuropean UnionVILLUM Young InvestigatorEuropean Union’s Horizon 2020Horizon 2020Canada Foundation for InnovationOntario Research FundIn recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adArXivarXiv:2305.15453v2https://www.ebi.ac.uk/biostudies/studies/S-EPMC10274948biostudies-literatureDrugst.One - A plug-and-play solution for online systems medicine and network-based drug repurposing.PMC10274948777111#225404RE010-02013154965193#30865161L0214A22.00115PID2019-105500GB-I00RDI #34876101057619770827NSERC #20347516LW0243K422216132F031L0214ALevi HList MSaez-Rodriguez JShaked GZolotareva OBaumbach JBlumenthal DBGarcia-Hernandez CHartung MOubounyt MBaier SSarkar SWang RJurisica IBader GDPillich RTLobentanzer SManz QLazareva OSadegh SChen JLoscalzo JMatschinske JPico ARPratt DAbovsky MElkjaer MLMalod-Dognin NTrummer NPoschenrieder JMTurhan UMee MHelmy MHoffmann MShamir RMaier AAdamowicz KPrzulj NKotlyar MfalseDrugst.One - A plug-and-play solution for online systems medicine and network-based drug repurposing.In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad ad2023-01-01T00:00:00Z2023 Jul2026-06-16T03:13:45.304Z2026-06-16T03:07:23.869ZS-EPMC102749483733256710.1093/nar/gkae388