biostudies-literatureUnknown43(5)Dorsey MJLeadiant Biosciences, Inc.<h4>Purpose</h4>Metabolic detoxification with enzyme replacement therapy (ERT) promotes immune recovery in patients with adenosine deaminase (ADA)-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase is a PEGylated recombinant bovine ADA ERT developed to replace the now-discontinued bovine-derived pegademase. This study was a 1-way crossover from pegademase to elapegademase in 7 patients with ADA-SCID to assess efficacy and safety outcomes for elapegademase.<h4>Methods</h4>After once-weekly pegademase dosage was adjusted to achieve therapeutic metabolic detoxification and trough ADA activity, patients transitioned to a bioequivalent dose of elapegademase. Maintenance of metabolic detoxification and adequate ADA activity were evaluated periodically.<h4>Results</h4>One patienJournal of clinical immunology951-964https://www.ebi.ac.uk/biostudies/studies/S-EPMC10276086biostudies-literaturePEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID.PMC10276086Fausnight TWiley JMHaddad EDorsey MJLehman HRubinstein AfalsePEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID.<h4>Purpose</h4>Metabolic detoxification with enzyme replacement therapy (ERT) promotes immune recovery in patients with adenosine deaminase (ADA)-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase is a PEGylated recombinant bovine ADA ERT developed to replace the now-discontinued bovine-derived pegademase. This study was a 1-way crossover from pegademase to elapegademase in 7 patients with ADA-SCID to assess efficacy and safety outcomes for elapegademase.<h4>Methods</h4>After once-weekly pegademase dosage was adjusted to achieve therapeutic metabolic detoxification and trough ADA activity, patients transitioned to a bioequivalent dose of elapegademase. Maintenance of metabolic detoxification and adequate ADA activity were evaluated periodically.<h4>Results</h4>One patien2023-01-01T00:00:00Z2023 Jul2025-04-22T02:05:57.301Z2025-04-05T20:13:42.109ZS-EPMC102760863684083510.1007/s10875-022-01426-y