{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu F"],"funding":["Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)"],"pagination":["3611"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10276816"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1+CXCR5+Bcl6+CD4+ T cells will differentiate into PD-1hiCXCR5hiBcl6hi GC-Tfh cells and how GC-Tfh cell differentiation is regulated. Here, we report that the sustained Tigit expression in PD-1+CXCR5+CD4+ T cells marks the precursor Tfh (pre-Tfh) to GC-Tfh transition, whereas Tigit-PD-1+CXCR5+CD4+ T cells upregulate IL-7Rα to become CXCR5+CD4+ T memory cells with or without CCR7. We demonstrate that pre-Tfh cells undergo substantial further differentiation at the transcriptome and chromatin access"],"journal":["Nature communications"],"pubmed_title":["Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate."],"pmcid":["PMC10276816"],"funding_grant_id":["T32AI007051","AI122842","AI133679","T32AR069516","T32GM008361","AI130232","AI167986","AI116188"],"pubmed_authors":["Xia X","Harada Y","Gonzalez-Avalos E","Chandler KM","Zhu F","Schroeder AR","Brown ER","Sialer DO","Greer BD","Wang YH","Pipkin ME","Hu H","Getzler AJ","Figge D","Kutsch O","McMonigle RJ","Xiao C"],"additional_accession":[]},"is_claimable":false,"name":"Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate.","description":"Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1+CXCR5+Bcl6+CD4+ T cells will differentiate into PD-1hiCXCR5hiBcl6hi GC-Tfh cells and how GC-Tfh cell differentiation is regulated. Here, we report that the sustained Tigit expression in PD-1+CXCR5+CD4+ T cells marks the precursor Tfh (pre-Tfh) to GC-Tfh transition, whereas Tigit-PD-1+CXCR5+CD4+ T cells upregulate IL-7Rα to become CXCR5+CD4+ T memory cells with or without CCR7. We demonstrate that pre-Tfh cells undergo substantial further differentiation at the transcriptome and chromatin access","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-22T01:59:06.693Z","creation":"2025-04-05T20:11:50.568Z"},"accession":"S-EPMC10276816","cross_references":{"pubmed":["37330549"],"doi":["10.1038/s41467-023-39299-3"]}}