biostudies-literatureTisi SCancer Research UKGRAIL IncNational Institute for Health Research (NIHR)Wellcome Truste001664https://www.ebi.ac.uk/biostudies/studies/S-EPMC10277548biostudies-literatureUnknown10(1)<h4>Background</h4>Pulmonary and extrapulmonary incidental findings are frequently identified on CT scans performed for lung cancer screening. Uncertainty regarding their clinical significance and how and when such findings should be reported back to clinicians and participants persists. We examined the prevalence of non-malignant incidental findings within a lung cancer screening cohort and investigated the morbidity and relevant risk factors associated with incidental findings. We quantified the primary and secondary care referrals generated by our protocol.<h4>Methods</h4>The SUMMIT study (NCT03934866) is a prospective observational cohort study to examine the performance of delivering a low-dose CT (LDCT) screening service to a high-risk population. Spirometry, blood pressure, height/wBMJ open respiratory researchPrevalence and clinical characteristics of non-malignant CT detected incidental findings in the SUMMIT lung cancer screening cohort.PMC10277548WT107963AIACTUQQR-DEC22/100009EDDCPGM\100002Not Applicable28706Patel AParry-Billings KO'Shaughnessy TCotton AClark MJanes SHanif ZMiah MStefan ECrossingham ATaniaAnastasiadis APTaylor MTeague JSamson AVerghese PJacob JPatel UArancon DBhowmik AEng JSarpong RMehta SNeville AMcEwen RMangera ZScreaton NEllis SVillanueva AGowers KAirebamen JHackshaw ABuchan TChan KHall HHacker AMQuaife SLAziz TDavies KJanes SMNnorom SLevermore CPrendecki RPhua KHurst JRRicketts WMDickson JEl-Emir ELock SGyertson KBeech NHorst CTisi SCreamer ABhamani ABojang FKiconco HOvayolu DZylstra JRusius JBanka RHare SCash CSayer CNavani NMullin AMRowlands JMurali EPervez HIfe CMcKee JEnes SPRobbie HGallagher LHosein CRobinson PQuaife SNundlall NDevaraj ACreamer AWGreen LSennett KNeville QALimani TDickson JLFarrelly LEkeowa UBowyer VSUMMIT ConsortiumCallender TRuparel MHoque FEdey AMcCabe JRobinson GNair ASuresh MfalsePrevalence and clinical characteristics of non-malignant CT detected incidental findings in the SUMMIT lung cancer screening cohort.<h4>Background</h4>Pulmonary and extrapulmonary incidental findings are frequently identified on CT scans performed for lung cancer screening. Uncertainty regarding their clinical significance and how and when such findings should be reported back to clinicians and participants persists. We examined the prevalence of non-malignant incidental findings within a lung cancer screening cohort and investigated the morbidity and relevant risk factors associated with incidental findings. We quantified the primary and secondary care referrals generated by our protocol.<h4>Methods</h4>The SUMMIT study (NCT03934866) is a prospective observational cohort study to examine the performance of delivering a low-dose CT (LDCT) screening service to a high-risk population. Spirometry, blood pressure, height/w2023-01-01T00:00:00Z2023 Jun2026-07-14T17:17:32.753Z2026-06-21T03:12:39.643ZS-EPMC102775483732166510.1136/bmjresp-2023-001664