biostudies-literatureUnknown13Rebane-Klemm EIn colorectal cancer (CRC) energy metabolism research, the precancerous stage of polyp has remained rather unexplored. By now, it has been shown that CRC has not fully obtained the glycolytic phenotype proposed by O. Warburg and rather depends on mitochondrial respiration. However, the pattern of metabolic adaptations during tumorigenesis is still unknown. Understanding the interplay between genetic and metabolic changes that initiate tumor development could provide biomarkers for diagnosing cancer early and targets for new cancer therapeutics. We used human CRC and polyp tissue material and performed high-resolution respirometry and qRT-PCR to detect changes on molecular and functional level with the goal of generally describing metabolic reprogramming during CRC development. Colon polypsFrontiers in oncology1171887https://www.ebi.ac.uk/biostudies/studies/S-EPMC10277630biostudies-literatureColorectal polyps increase the glycolytic activity.PMC10277630Suurmaa KKaambre TShevchuk IValvere VPuurand MRebane-Klemm EBogovskaja JMoreno-Sanchez RReinsalu LfalseColorectal polyps increase the glycolytic activity.In colorectal cancer (CRC) energy metabolism research, the precancerous stage of polyp has remained rather unexplored. By now, it has been shown that CRC has not fully obtained the glycolytic phenotype proposed by O. Warburg and rather depends on mitochondrial respiration. However, the pattern of metabolic adaptations during tumorigenesis is still unknown. Understanding the interplay between genetic and metabolic changes that initiate tumor development could provide biomarkers for diagnosing cancer early and targets for new cancer therapeutics. We used human CRC and polyp tissue material and performed high-resolution respirometry and qRT-PCR to detect changes on molecular and functional level with the goal of generally describing metabolic reprogramming during CRC development. Colon polyps2023-01-01T00:00:00Z20232025-04-26T09:03:00.046Z2025-04-06T12:56:14.414ZS-EPMC102776303734218310.3389/fonc.2023.1171887