{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yuan XQ"],"funding":["Fundamental Research Funds for the Central Universities","Basic and Applied Basic Research Foundation of Guangdong Province","Guangdong Provincial Natural Science Foundation","National Natural Science Foundation of China","China Postdoctoral Science Foundation","National Postdoctoral Program for Innovative Talents"],"pagination":["1756-1774"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10277835"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(6)"],"pubmed_abstract":["Super-enhancer (SE) plays a vital role in the determination of cell identity and fate. Up-regulated expression of coding genes is frequently associated with SE. However, the transcription dysregulation driven by SE, from the viewpoint of long non-coding RNA (lncRNA), remains unclear. Here, SE-associated lncRNAs in HCC are comprehensively outlined for the first time. This study integrally screens and identifies several novel SE-associated lncRNAs that are highly abundant and sensitive to JQ1. Especially, HSAL3 is identified as an uncharacterized SE-driven oncogenic lncRNA, which is activated by transcription factors HCFC1 and HSF1 via its super-enhancer. HSAL3 interference negatively regulates NOTCH signaling, implying the potential mechanism of its tumor-promoting role. The expression of H"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pubmed_title":["Anchoring super-enhancer-driven oncogenic lncRNAs for anti-tumor therapy in hepatocellular carcinoma."],"pmcid":["PMC10277835"],"funding_grant_id":["2019A1515012114","81802812","2019M663254","2018A030313129","BX20190395","81803636","81972658","2018A0303130329","20ykpy105"],"pubmed_authors":["Li GC","Wang JP","Zhou N","Wang S","Yuan XQ","Peng L","Yang XZ","Zhang CY"],"additional_accession":[]},"is_claimable":false,"name":"Anchoring super-enhancer-driven oncogenic lncRNAs for anti-tumor therapy in hepatocellular carcinoma.","description":"Super-enhancer (SE) plays a vital role in the determination of cell identity and fate. Up-regulated expression of coding genes is frequently associated with SE. However, the transcription dysregulation driven by SE, from the viewpoint of long non-coding RNA (lncRNA), remains unclear. Here, SE-associated lncRNAs in HCC are comprehensively outlined for the first time. This study integrally screens and identifies several novel SE-associated lncRNAs that are highly abundant and sensitive to JQ1. Especially, HSAL3 is identified as an uncharacterized SE-driven oncogenic lncRNA, which is activated by transcription factors HCFC1 and HSF1 via its super-enhancer. HSAL3 interference negatively regulates NOTCH signaling, implying the potential mechanism of its tumor-promoting role. The expression of H","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-06-01T10:59:10.924Z","creation":"2026-04-08T11:40:23.232Z"},"accession":"S-EPMC10277835","cross_references":{"pubmed":["36461633"],"doi":["10.1016/j.ymthe.2022.11.013"]}}