{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(6)"],"submitter":["Xu X"],"pubmed_abstract":["N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A) RNA modification, methylation at the N6 position of adenosine, plays critical roles in tumorigenesis. m<sup>6</sup>A readers recognize m<sup>6</sup>A modifications and thus act as key executors for the biological consequences of RNA methylation. However, knowledge about the regulatory mechanism(s) of m<sup>6</sup>A readers is extremely limited. In this study, RN7SK was identified as a small nuclear RNA that interacts with m<sup>6</sup>A readers. m<sup>6</sup>A readers recognized and facilitated secondary structure formation of m<sup>6</sup>A-modified RN7SK, which in turn prevented m<sup>6</sup>A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m<sup>6</sup>A readers is established in tumor cells. F"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pagination":["1615-1635"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10277899"],"repository":["biostudies-literature"],"pubmed_title":["A positive feedback circuit between RN7SK snRNA and m<sup>6</sup>A readers is essential for tumorigenesis."],"pmcid":["PMC10277899"],"pubmed_authors":["Ma L","Qiu S","Tian X","Zhang X","Guo W","Miao Y","Guo S","Xu X","Wang Y","Wang J","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"A positive feedback circuit between RN7SK snRNA and m<sup>6</sup>A readers is essential for tumorigenesis.","description":"N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A) RNA modification, methylation at the N6 position of adenosine, plays critical roles in tumorigenesis. m<sup>6</sup>A readers recognize m<sup>6</sup>A modifications and thus act as key executors for the biological consequences of RNA methylation. However, knowledge about the regulatory mechanism(s) of m<sup>6</sup>A readers is extremely limited. In this study, RN7SK was identified as a small nuclear RNA that interacts with m<sup>6</sup>A readers. m<sup>6</sup>A readers recognized and facilitated secondary structure formation of m<sup>6</sup>A-modified RN7SK, which in turn prevented m<sup>6</sup>A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m<sup>6</sup>A readers is established in tumor cells. F","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-06-01T10:58:52.188Z","creation":"2026-04-08T11:39:46.386Z"},"accession":"S-EPMC10277899","cross_references":{"pubmed":["36566349"],"doi":["10.1016/j.ymthe.2022.12.013"]}}