biostudies-literatureLieber SBNCATS NIH HHS60-67https://www.ebi.ac.uk/biostudies/studies/S-EPMC10279522biostudies-literatureUnknown49(1)<h4>Objective</h4>Frailty is associated with mortality in systemic lupus erythematosus (SLE), but how best to measure frailty is unclear. We aimed to compare 2 frailty metrics, the self-reported Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale (FS) and the Fried phenotype (FP), in SLE to evaluate differences between frail and nonfrail women and whether frailty is associated with self-reported disability.<h4>Methods</h4>Adult women aged < 70 years with validated SLE and mild/moderate disease enrolled in this cross-sectional study between August 2018 and October 2019. Correlation and agreement between the FS and the FP were determined. Differences in sociodemographic and disease characteristics, patient-reported outcome measures (PROMs), and biomarkers between fraThe Journal of rheumatologyEvaluation of a Patient-reported Frailty Tool in Women With Systemic Lupus Erythematosus.PMC10279522UL1 TR002384Barbhaiya MSheira DBerman JRLieber SBSammaritano LRNahid MPaget SCarrino JARajan MMandl LAKirou KfalseEvaluation of a Patient-reported Frailty Tool in Women With Systemic Lupus Erythematosus.<h4>Objective</h4>Frailty is associated with mortality in systemic lupus erythematosus (SLE), but how best to measure frailty is unclear. We aimed to compare 2 frailty metrics, the self-reported Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale (FS) and the Fried phenotype (FP), in SLE to evaluate differences between frail and nonfrail women and whether frailty is associated with self-reported disability.<h4>Methods</h4>Adult women aged < 70 years with validated SLE and mild/moderate disease enrolled in this cross-sectional study between August 2018 and October 2019. Correlation and agreement between the FS and the FP were determined. Differences in sociodemographic and disease characteristics, patient-reported outcome measures (PROMs), and biomarkers between fra2022-01-01T00:00:00Z2022 Jan2025-04-05T13:54:41.682Z2025-02-19T03:56:23.85ZS-EPMC102795223447079510.3899/jrheum.201466