{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Xu J"],"funding":["Beijing University of Chinese Medicine","Guizhou Medical University"],"pubmed_abstract":["Curcumin is well known as a potent antioxidant and free radical scavenger and has great potential for anti-aging applications. In this study, we investigate the molecular mechanism of curcumin in prolonging the lifespan of <i>C. elegans</i>. Four concentrations of curcumin (10, 25, 50, and 100 µM) were administered, and the optimal treatment concentration was determined by analyzing the nematode lifespan, physiology, and biochemistry. Additionally, RNA-seq and qRT-PCR were performed to explore the antioxidant effect of curcumin and its underlying mechanism. Results revealed that curcumin could significantly improve the survival capacity of <i>C. elegans</i> without influencing its growth. Curcumin was observed to significantly decrease the levels of reactive oxygen species (ROS) under extr"],"journal":["Frontiers in pharmacology"],"pagination":["1195490"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10279890"],"repository":["biostudies-literature"],"pubmed_title":["Curcumin supplementation increases longevity and antioxidant capacity in <i>Caenorhabditis elegans</i>."],"pmcid":["PMC10279890"],"pubmed_authors":["Liu X","Du P","Ge Y","Xu X","Zhang C","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"Curcumin supplementation increases longevity and antioxidant capacity in <i>Caenorhabditis elegans</i>.","description":"Curcumin is well known as a potent antioxidant and free radical scavenger and has great potential for anti-aging applications. In this study, we investigate the molecular mechanism of curcumin in prolonging the lifespan of <i>C. elegans</i>. Four concentrations of curcumin (10, 25, 50, and 100 µM) were administered, and the optimal treatment concentration was determined by analyzing the nematode lifespan, physiology, and biochemistry. Additionally, RNA-seq and qRT-PCR were performed to explore the antioxidant effect of curcumin and its underlying mechanism. Results revealed that curcumin could significantly improve the survival capacity of <i>C. elegans</i> without influencing its growth. Curcumin was observed to significantly decrease the levels of reactive oxygen species (ROS) under extr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-07T13:30:09.532Z","creation":"2025-02-19T04:30:18.193Z"},"accession":"S-EPMC10279890","cross_references":{"pubmed":["37346299"],"doi":["10.3389/fphar.2023.1195490"]}}