biostudies-literatureUnknown4(4)Li JAlzheimer's disease (AD) is a common form of neurodegenerative disease in the elderly. Amyloid-β (Aβ)-associated neurotoxicity is an important component of the neurodegenerative change in AD. Recent studies have revealed a beneficial effect of anthocyanins in improving learning and memory in AD animal models. Using cultured HT22 mouse hippocampal neuronal cells as an in vitro model, we examined in this study the protective effect of ten pure components of anthocyanins against Aβ 42-induced cytotoxicity and also investigated the mechanism of their protective effects. We found that treatment of HT22 cells with the pure components of anthocyanins dose-dependently rescued Aβ 42-induced cytotoxicity, with slightly different potencies. Using petuMedComme301https://www.ebi.ac.uk/biostudies/studies/S-EPMC10279944biostudies-literatureAttenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells.PMC10279944Hou MJLi JWang PZhu BTfalseAttenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells.Alzheimer's disease (AD) is a common form of neurodegenerative disease in the elderly. Amyloid-β (Aβ)-associated neurotoxicity is an important component of the neurodegenerative change in AD. Recent studies have revealed a beneficial effect of anthocyanins in improving learning and memory in AD animal models. Using cultured HT22 mouse hippocampal neuronal cells as an in vitro model, we examined in this study the protective effect of ten pure components of anthocyanins against Aβ 42-induced cytotoxicity and also investigated the mechanism of their protective effects. We found that treatment of HT22 cells with the pure components of anthocyanins dose-dependently rescued Aβ 42-induced cytotoxicity, with slightly different potencies. Using petu2023-01-01T00:00:00Z2023 Aug2025-04-05T13:54:13.937Z2025-04-05T13:54:13.937ZS-EPMC102799443734693410.1002/mco2.301