{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu D"],"funding":["China Agriculture Research System of MOF and MARA","National Key R&D Program of China","Young Top-notch Talent Project of the National Ten Thousand Talent Program","The Agricultural Science and Technology Innovation Program","National Natural Science Foundation of China"],"pagination":["e2300148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10288243"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(18)"],"pubmed_abstract":["Meat is among the most consumed foods worldwide and has a unique flavor and high nutrient density in the human diet. However, the genetic and biochemical bases of meat nutrition and flavor are poorly understood. Here, 3431 metabolites and 702 volatiles in 423 skeletal muscle samples are profiled from a gradient consanguinity segregating population generated by Pekin duck × Liancheng duck crosses using metabolomic approaches. The authors identified 2862 metabolome-based genome-wide association studies (mGWAS) signals and 48 candidate genes potentially modulating metabolite and volatile levels, 79.2% of which are regulated by cis-regulatory elements. The level of plasmalogen is significantly associated with TMEM189 encoding plasmanylethanolamine desaturase 1. The levels of 2-pyrrolidone and "],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights."],"pmcid":["PMC10288243"],"funding_grant_id":["31972523","2022YFF1000100","CAAS-ZDRW202104","ASTIP-IAS-9","CARS-42-5"],"pubmed_authors":["Liu H","Fan W","Guo Z","Yu S","Cao J","Zhang H","Yu D","Hou S","Liu T","Gai K","Tang H","Zhou Z","Yang X","Tang J","Yang Y","Mou Q","Hu J","Liu D","Wang Z","Zhang B"],"additional_accession":[]},"is_claimable":false,"name":"Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights.","description":"Meat is among the most consumed foods worldwide and has a unique flavor and high nutrient density in the human diet. However, the genetic and biochemical bases of meat nutrition and flavor are poorly understood. Here, 3431 metabolites and 702 volatiles in 423 skeletal muscle samples are profiled from a gradient consanguinity segregating population generated by Pekin duck × Liancheng duck crosses using metabolomic approaches. The authors identified 2862 metabolome-based genome-wide association studies (mGWAS) signals and 48 candidate genes potentially modulating metabolite and volatile levels, 79.2% of which are regulated by cis-regulatory elements. The level of plasmalogen is significantly associated with TMEM189 encoding plasmanylethanolamine desaturase 1. The levels of 2-pyrrolidone and ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T12:10:58.618Z","creation":"2025-04-04T12:10:58.618Z"},"accession":"S-EPMC10288243","cross_references":{"pubmed":["37013465"],"doi":["10.1002/advs.202300148"]}}