{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32(3)"],"submitter":["Ekawaravong S"],"pubmed_abstract":["Serum cortisol mainly binds to the cortisol-binding globulin (CBG). Children with biliary atresia (BA) may have low serum CBG levels; thus, low serum total cortisol (TC) levels and adrenal insufficiency (AI) may be overdiagnosed. This study aimed to assess adrenal function in children with BA. All the patients underwent adrenocorticotropic hormone (ACTH) stimulation tests. Plasma ACTH, serum TC, and CBG levels were measured at baseline, with additional TC measurements at 30 and 60 min during testing. Free cortisol (FC) index (FCI) and calculated FC (cFC) were also calculated. AI was defined as peak TC <500 nmol/L (<18 μg/dL), peak FCI <12 nmol/mg, or peak cFC <33 nmol/L (<1.2 μg/dL). This study enrolled 71 children with BA. The Median (IQR) age of the patients was 5.5 (1.7-11.4) years. Twe"],"journal":["Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology"],"pagination":["147-154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10288293"],"repository":["biostudies-literature"],"pubmed_title":["Overdiagnosis of adrenal insufficiency in children with biliary atresia."],"pmcid":["PMC10288293"],"pubmed_authors":["Ekawaravong S","Treepongkaruna S","Pongratanakul S","Khlairit P","Poomthavorn P","Chanprasertyothin S","Mahachoklertwattana P"],"additional_accession":[]},"is_claimable":false,"name":"Overdiagnosis of adrenal insufficiency in children with biliary atresia.","description":"Serum cortisol mainly binds to the cortisol-binding globulin (CBG). Children with biliary atresia (BA) may have low serum CBG levels; thus, low serum total cortisol (TC) levels and adrenal insufficiency (AI) may be overdiagnosed. This study aimed to assess adrenal function in children with BA. All the patients underwent adrenocorticotropic hormone (ACTH) stimulation tests. Plasma ACTH, serum TC, and CBG levels were measured at baseline, with additional TC measurements at 30 and 60 min during testing. Free cortisol (FC) index (FCI) and calculated FC (cFC) were also calculated. AI was defined as peak TC <500 nmol/L (<18 μg/dL), peak FCI <12 nmol/mg, or peak cFC <33 nmol/L (<1.2 μg/dL). This study enrolled 71 children with BA. The Median (IQR) age of the patients was 5.5 (1.7-11.4) years. Twe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T12:10:58.417Z","creation":"2025-04-04T12:10:58.417Z"},"accession":"S-EPMC10288293","cross_references":{"pubmed":["37362167"],"doi":["10.1297/cpe.2022-0083"]}}