biostudies-literatureWu LLScience and Technology Commission of Shanghai MunicipalityShanghai ShenKang Hospital Development Centre168https://www.ebi.ac.uk/biostudies/studies/S-EPMC10288722biostudies-literatureUnknown24(1)<h4>Background</h4>The current nodal (pN) classification still has limitations in stratifying the prognosis of small cell lung cancer (SCLC) patients with pathological classifications T1-2N0-2M0. Thus. This study aimed to develop and validate a modified nodal classification based on a multicenter cohort.<h4>Materials and methods</h4>We collected 1156 SCLC patients with pathological classifications T1-2N0-2M0 from the Surveillance, Epidemiology, and End Results database and a multicenter database in China. The X-tile software was conducted to determine the optimal cutoff points of the number of examined lymph nodes (ELNs) and lymph node ratio (LNR). The Kaplan-Meier method, the Log-rank test, and the Cox regression method were used in this study. We classified patients into three pathologicRespiratory researchReconsidering N component of cancer staging for T1-2N0-2M0 small-cell lung cancer: a retrospective study based on multicenter cohort.PMC10288722SHDC2202021821Y11913400Lin PLong HQian JYJiang FZhang LJLi CWQiu LHYu WJLi KXie DLiang SHMa GWChen XWu LLLi ZXfalseReconsidering N component of cancer staging for T1-2N0-2M0 small-cell lung cancer: a retrospective study based on multicenter cohort.<h4>Background</h4>The current nodal (pN) classification still has limitations in stratifying the prognosis of small cell lung cancer (SCLC) patients with pathological classifications T1-2N0-2M0. Thus. This study aimed to develop and validate a modified nodal classification based on a multicenter cohort.<h4>Materials and methods</h4>We collected 1156 SCLC patients with pathological classifications T1-2N0-2M0 from the Surveillance, Epidemiology, and End Results database and a multicenter database in China. The X-tile software was conducted to determine the optimal cutoff points of the number of examined lymph nodes (ELNs) and lymph node ratio (LNR). The Kaplan-Meier method, the Log-rank test, and the Cox regression method were used in this study. We classified patients into three pathologic2023-01-01T00:00:00Z2023 Jun2025-04-04T12:10:49.059Z2025-04-04T12:10:49.059ZS-EPMC102887223735378210.1186/s12931-023-02440-3