biostudies-literatureMartinez-Perez-Cejuela HUniversitat de ValenciaMinisterio de Ciencia e Innovación271https://www.ebi.ac.uk/biostudies/studies/S-EPMC10289984biostudies-literatureUnknown190(7)A new concept of paper-based device has been developed combining the advantages of cellulose supports and the rich surface chemistry of metal-organic frameworks (MOFs). The composite, named as NH₂-UiO-66@paper, has been developed for the isolation of synthetic cannabinoid receptor agonists (SCRAs) in oral fluids, trying to mimic the interactions of those compounds with the human CB1R and CB2R receptors, mainly governed by hydrogen bonding and π-interactions with serine and histidine residues. MOF selection (UiO-66) and functionalization of the ligand (2-aminoterephthalic acid) has been done according to the following criteria: (i) water stability of the selected MOF, and (ii) promoting appropriate interactions with SCRAs due to the MOF nature. NH₂-UiO-66@paper composiMikrochimica actaMicro-paper-based analytical device decorated with metal-organic frameworks for the assay of synthetic cannabinoids in oral fluids coupled to ion mobility spectrometry.PMC10289984PID2021-126304OB-C43PID2021-125459OB-I00PID2019-110788GB-I00Herrero-Martinez JMGarcia-Atienza PSimo-Alfonso EFMartinez-Perez-Cejuela HArmenta SfalseMicro-paper-based analytical device decorated with metal-organic frameworks for the assay of synthetic cannabinoids in oral fluids coupled to ion mobility spectrometry.A new concept of paper-based device has been developed combining the advantages of cellulose supports and the rich surface chemistry of metal-organic frameworks (MOFs). The composite, named as NH₂-UiO-66@paper, has been developed for the isolation of synthetic cannabinoid receptor agonists (SCRAs) in oral fluids, trying to mimic the interactions of those compounds with the human CB1R and CB2R receptors, mainly governed by hydrogen bonding and π-interactions with serine and histidine residues. MOF selection (UiO-66) and functionalization of the ligand (2-aminoterephthalic acid) has been done according to the following criteria: (i) water stability of the selected MOF, and (ii) promoting appropriate interactions with SCRAs due to the MOF nature. NH₂-UiO-66@paper composi2023-01-01T00:00:00Z2023 Jun2025-05-29T16:07:04.862Z2025-04-04T18:42:57.116ZS-EPMC102899843735164910.1007/s00604-023-05844-6