{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garrett L"],"funding":["German Center for Diabetes Research","Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)","German federal ministerium of Education and Research"],"pagination":["331-350"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10290621"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(2)"],"pubmed_abstract":["Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding, biomarker identification and therapeutic strategy. Emerging evidence implicates heart/brain axis malfunction in NPD etiology, particularly via the autonomic nervous system (ANS) and brain central autonomic network (CAN) interaction. This heart/brain inter-relationship harbors potentially novel NPD diagnosis and treatment avenues. Nevertheless, the lack of multidisciplinary clinical approaches as well as a limited appreciation of molecular underpinnings has stymied progress. Large-scale preclinical multi-systemic functional data can therefore provide supplementary insight into CAN and ANS interaction. We here present an overview of the heart/brain ax"],"journal":["Mammalian genome : official journal of the International Mammalian Genome Society"],"pubmed_title":["A rationale for considering heart/brain axis control in neuropsychiatric disease."],"pmcid":["PMC10290621"],"funding_grant_id":["01KX1012"],"pubmed_authors":["Hrabe de Angelis M","Garrett L","Holter SM","Fuchs H","Trumbach D","Wurst W","Spielmann N","Gailus-Durner V"],"additional_accession":[]},"is_claimable":false,"name":"A rationale for considering heart/brain axis control in neuropsychiatric disease.","description":"Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding, biomarker identification and therapeutic strategy. Emerging evidence implicates heart/brain axis malfunction in NPD etiology, particularly via the autonomic nervous system (ANS) and brain central autonomic network (CAN) interaction. This heart/brain inter-relationship harbors potentially novel NPD diagnosis and treatment avenues. Nevertheless, the lack of multidisciplinary clinical approaches as well as a limited appreciation of molecular underpinnings has stymied progress. Large-scale preclinical multi-systemic functional data can therefore provide supplementary insight into CAN and ANS interaction. We here present an overview of the heart/brain ax","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T11:51:59.059Z","creation":"2025-04-04T11:51:59.059Z"},"accession":"S-EPMC10290621","cross_references":{"pubmed":["36538124"],"doi":["10.1007/s00335-022-09974-9"]}}