biostudies-literatureGarrett LGerman Center for Diabetes ResearchHelmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)German federal ministerium of Education and Research331-350https://www.ebi.ac.uk/biostudies/studies/S-EPMC10290621biostudies-literatureUnknown34(2)Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding, biomarker identification and therapeutic strategy. Emerging evidence implicates heart/brain axis malfunction in NPD etiology, particularly via the autonomic nervous system (ANS) and brain central autonomic network (CAN) interaction. This heart/brain inter-relationship harbors potentially novel NPD diagnosis and treatment avenues. Nevertheless, the lack of multidisciplinary clinical approaches as well as a limited appreciation of molecular underpinnings has stymied progress. Large-scale preclinical multi-systemic functional data can therefore provide supplementary insight into CAN and ANS interaction. We here present an overview of the heart/brain axMammalian genome : official journal of the International Mammalian Genome SocietyA rationale for considering heart/brain axis control in neuropsychiatric disease.PMC1029062101KX1012Hrabe de Angelis MGarrett LHolter SMFuchs HTrumbach DWurst WSpielmann NGailus-Durner VfalseA rationale for considering heart/brain axis control in neuropsychiatric disease.Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding, biomarker identification and therapeutic strategy. Emerging evidence implicates heart/brain axis malfunction in NPD etiology, particularly via the autonomic nervous system (ANS) and brain central autonomic network (CAN) interaction. This heart/brain inter-relationship harbors potentially novel NPD diagnosis and treatment avenues. Nevertheless, the lack of multidisciplinary clinical approaches as well as a limited appreciation of molecular underpinnings has stymied progress. Large-scale preclinical multi-systemic functional data can therefore provide supplementary insight into CAN and ANS interaction. We here present an overview of the heart/brain ax2023-01-01T00:00:00Z2023 Jun2025-04-04T11:51:59.059Z2025-04-04T11:51:59.059ZS-EPMC102906213653812410.1007/s00335-022-09974-9