biostudies-literatureUnknown11Yang P<h4>Background</h4>Preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) may optimize individualized treatment decision-making. This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection (LR) and liver transplantation (LT) based on predicted MVI risks.<h4>Methods</h4>We analysed 905 patients who underwent LR, including 524 who underwent anatomical resection (AR) and 117 who underwent LT for HCC within the Milan criteria using propensity score matching. A nomogram model was used to predict preoperative MVI risk.<h4>Results</h4>The concordance indices of the nomogram for predicting MVI were 0.809 and 0.838 in patients undergoing LR and LT, respectively. Based on an optimal cut-off value of 200 points, the nomGastroenterology reportgoad035https://www.ebi.ac.uk/biostudies/studies/S-EPMC10293589biostudies-literatureLiver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks.PMC10293589Xia YLi JXie ZFu ZTeng FWan XShen HWang KCheng ZPawlik TMShen FYin HBai SLei ZYang PYang TZhang BLau WYfalseLiver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks.<h4>Background</h4>Preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) may optimize individualized treatment decision-making. This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection (LR) and liver transplantation (LT) based on predicted MVI risks.<h4>Methods</h4>We analysed 905 patients who underwent LR, including 524 who underwent anatomical resection (AR) and 117 who underwent LT for HCC within the Milan criteria using propensity score matching. A nomogram model was used to predict preoperative MVI risk.<h4>Results</h4>The concordance indices of the nomogram for predicting MVI were 0.809 and 0.838 in patients undergoing LR and LT, respectively. Based on an optimal cut-off value of 200 points, the nom2023-01-01T00:00:00Z20232025-04-22T09:46:12.15Z2025-04-05T23:17:17.744ZS-EPMC102935893738411910.1093/gastro/goad035