{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karimzadeh M"],"funding":["Ontario Institute for Cancer Research","Princess Margaret Cancer Foundation","Peterborough K. M. Hunter Charitable Foundation","Canadian Cancer Society","Ontario Ministry of Training, Colleges and Universities","Parya Trillium Foundation","University of Toronto"],"pagination":["142"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10294493"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV. We hypothesize that changes in chromatin state at the location of integration can result in changes in gene expression that contribute to the tumorigenicity of HPV.<h4>Results</h4>We find that viral integration events often occur along with changes in chromatin state and expression of genes near the integration site. We investigate whether introduction of new transcription factor binding sites due to HPV integration could invoke these changes. Some regions within the HPV genome, particularly the position of a conserved CTCF binding site, show enriched chromatin accessibility signa"],"journal":["Genome biology"],"pubmed_title":["Human papillomavirus integration transforms chromatin to drive oncogenesis."],"pmcid":["PMC10294493"],"funding_grant_id":["703827"],"pubmed_authors":["Lupien M","Arlidge C","Karimzadeh M","Rostami A","Bratman SV","Hoffman MM"],"additional_accession":[]},"is_claimable":false,"name":"Human papillomavirus integration transforms chromatin to drive oncogenesis.","description":"<h4>Background</h4>Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV. We hypothesize that changes in chromatin state at the location of integration can result in changes in gene expression that contribute to the tumorigenicity of HPV.<h4>Results</h4>We find that viral integration events often occur along with changes in chromatin state and expression of genes near the integration site. We investigate whether introduction of new transcription factor binding sites due to HPV integration could invoke these changes. Some regions within the HPV genome, particularly the position of a conserved CTCF binding site, show enriched chromatin accessibility signa","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2026-04-29T02:28:04.112Z","creation":"2025-02-19T01:19:25.264Z"},"accession":"S-EPMC10294493","cross_references":{"pubmed":["37365652"],"doi":["10.1186/s13059-023-02926-9"]}}