{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Couto-Rodriguez RL"],"funding":["NIH HHS"],"pagination":["1203"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10294847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Oxidative stress adaptation strategies are important to cell function and are linked to cardiac, neurodegenerative disease, and cancer. Representatives of the <i>Archaea</i> domain are used as model organisms based on their extreme tolerance to oxidants and close evolutionary relationship with eukaryotes. A study of the halophilic archaeon <i>Haloferax volcanii</i> reveals lysine acetylation to be associated with oxidative stress responses. The strong oxidant hypochlorite: (i) stimulates an increase in lysine acetyltransferase <i>Hv</i>Pat2 to <i>Hv</i>Pat1 abundance ratios and (ii) selects for lysine deacetylase <i>sir2</i> mutants. Here we report the dynamic occupancy of the lysine acetylome of glycerol-grown <i>H. volcanii</i> as it shifts in profile in response to hypochlorite. These f"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Insights into the Lysine Acetylome of the Haloarchaeon <i>Haloferax volcanii</i> during Oxidative Stress by Quantitative SILAC-Based Proteomics."],"pmcid":["PMC10294847"],"funding_grant_id":["NIH R01 GM57498-20"],"pubmed_authors":["Couto-Rodriguez RL","Koh J","Chen S","Maupin-Furlow JA"],"additional_accession":[]},"is_claimable":false,"name":"Insights into the Lysine Acetylome of the Haloarchaeon <i>Haloferax volcanii</i> during Oxidative Stress by Quantitative SILAC-Based Proteomics.","description":"Oxidative stress adaptation strategies are important to cell function and are linked to cardiac, neurodegenerative disease, and cancer. Representatives of the <i>Archaea</i> domain are used as model organisms based on their extreme tolerance to oxidants and close evolutionary relationship with eukaryotes. A study of the halophilic archaeon <i>Haloferax volcanii</i> reveals lysine acetylation to be associated with oxidative stress responses. The strong oxidant hypochlorite: (i) stimulates an increase in lysine acetyltransferase <i>Hv</i>Pat2 to <i>Hv</i>Pat1 abundance ratios and (ii) selects for lysine deacetylase <i>sir2</i> mutants. Here we report the dynamic occupancy of the lysine acetylome of glycerol-grown <i>H. volcanii</i> as it shifts in profile in response to hypochlorite. These f","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-22T09:47:18.973Z","creation":"2025-04-05T23:14:06.206Z"},"accession":"S-EPMC10294847","cross_references":{"pubmed":["37371933"],"doi":["10.3390/antiox12061203"]}}