{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pahlow S"],"funding":["SARS-CoV-2Dx","Carl Zeiss Foundation","Photonics Research Germany","Federal Ministry of Education and Research"],"pagination":["594"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10296004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(6)"],"pubmed_abstract":["We introduce a magnetic bead-based sample preparation scheme for enabling the Raman spectroscopic differentiation of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-positive and -negative samples. The beads were functionalized with the angiotensin-converting enzyme 2 (ACE2) receptor protein, which is used as a recognition element to selectively enrich SARS-CoV-2 on the surface of the magnetic beads. The subsequent Raman measurements directly enable discriminating SARS-CoV-2-positive and -negative samples. The proposed approach is also applicable for other virus species when the specific recognition element is exchanged. A series of Raman spectra were measured on three types of samples, namely SARS-CoV-2, Influenza A H1N1 virus and a negative control. For each sample type,"],"journal":["Biosensors"],"pubmed_title":["Simple, Fast and Convenient Magnetic Bead-Based Sample Preparation for Detecting Viruses via Raman-Spectroscopy."],"pmcid":["PMC10296004"],"funding_grant_id":["13N15708, 13N15466","13N15708","13N15745","P2018-01-004","13N15466"],"pubmed_authors":["Weber K","Ryabchykov O","Richard-Lacroix M","Ehricht R","Hniopek J","Loffler B","Deinhardt-Emmer S","Pahlow S","Kose-Vogel N","Hornung F","Mayerhofer TG","Popp J","Bocklitz T"],"additional_accession":[]},"is_claimable":false,"name":"Simple, Fast and Convenient Magnetic Bead-Based Sample Preparation for Detecting Viruses via Raman-Spectroscopy.","description":"We introduce a magnetic bead-based sample preparation scheme for enabling the Raman spectroscopic differentiation of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-positive and -negative samples. The beads were functionalized with the angiotensin-converting enzyme 2 (ACE2) receptor protein, which is used as a recognition element to selectively enrich SARS-CoV-2 on the surface of the magnetic beads. The subsequent Raman measurements directly enable discriminating SARS-CoV-2-positive and -negative samples. The proposed approach is also applicable for other virus species when the specific recognition element is exchanged. A series of Raman spectra were measured on three types of samples, namely SARS-CoV-2, Influenza A H1N1 virus and a negative control. For each sample type,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-04-08T12:39:48.985Z","creation":"2025-04-07T10:22:21.097Z"},"accession":"S-EPMC10296004","cross_references":{"pubmed":["37366959"],"doi":["10.3390/bios13060594"]}}