{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee HJ"],"funding":["faculty research grant of Yonsei University College of Medicine","Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea","Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology","Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP","National Research Foundation of Korea (NRF) funded by the Ministry of Education"],"pagination":["1688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10296248"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(6)"],"pubmed_abstract":["Medullary thyroid cancer originates from parafollicular C-cells in the thyroid. Despite successful thyroidectomy, localizing remnant cancer cells in patients with elevated calcitonin and carcinoembryonic antigen levels remains a challenge. Extranasal odorant receptors are expressed in cells from non-olfactory tissues, including C-cells. This study evaluates the odorant receptor signals from parafollicular C-cells, specifically, the presence of olfactory marker protein, and further assesses the ability of the protein in localizing and treating medullary thyroid cancer. We used immunohistochemistry, immunofluorescent staining, Western blot, RNA sequencing, and real time-PCR to analyze the expression of odorant receptors in mice thyroids, thyroid cancer cell lines, and patient specimens. We u"],"journal":["Biomedicines"],"pubmed_title":["Acetate-Mediated Odorant Receptor OR51E2 Activation Results in Calcitonin Secretion in Parafollicular C-Cells: A Novel Diagnostic Target of Human Medullary Thyroid Cancer."],"pmcid":["PMC10296248"],"funding_grant_id":["6-2016-0078","NRF-2016R1D1A1B01014677","H14C1324","2019M3A9D5A01000073","2014M3A9B6069341"],"pubmed_authors":["Lee C","Kim D","Koo J","Ku CR","Kang CW","Cho YH","Lee EJ","Cho A","Lee HJ","Cho T"],"additional_accession":[]},"is_claimable":false,"name":"Acetate-Mediated Odorant Receptor OR51E2 Activation Results in Calcitonin Secretion in Parafollicular C-Cells: A Novel Diagnostic Target of Human Medullary Thyroid Cancer.","description":"Medullary thyroid cancer originates from parafollicular C-cells in the thyroid. Despite successful thyroidectomy, localizing remnant cancer cells in patients with elevated calcitonin and carcinoembryonic antigen levels remains a challenge. Extranasal odorant receptors are expressed in cells from non-olfactory tissues, including C-cells. This study evaluates the odorant receptor signals from parafollicular C-cells, specifically, the presence of olfactory marker protein, and further assesses the ability of the protein in localizing and treating medullary thyroid cancer. We used immunohistochemistry, immunofluorescent staining, Western blot, RNA sequencing, and real time-PCR to analyze the expression of odorant receptors in mice thyroids, thyroid cancer cell lines, and patient specimens. We u","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-19T08:59:19.86Z","creation":"2025-04-19T08:59:19.86Z"},"accession":"S-EPMC10296248","cross_references":{"pubmed":["37371783"],"doi":["10.3390/biomedicines11061688"]}}