biostudies-literatureFang XGuangzhou Science and Technology Plan ProjectMedical Science and Technology Foundation of Guangdong924https://www.ebi.ac.uk/biostudies/studies/S-EPMC10296568biostudies-literatureUnknown13(6)<h4>Background</h4>Blood-brain barrier dysfunction in active multiple sclerosis (MS) lesions leads to pathological changes in the cerebrospinal fluid (CSF). This study aimed to investigate the possible association between routine CSF findings, especially CSF chloride, at the time of the first lumbar puncture and the relapse risk and disability progression of relapsing-remitting MS (RRMS).<h4>Methods</h4>This retrospective study included 77 patients with RRMS at the MS Center of our institution from January 2012 to December 2020. The Anderson and Gill (AG) model and Spearman correlation analysis were used to explore predictors of relapse and disability during follow-up.<h4>Results</h4>In the multivariate AG model, patients with elevated CSF chloride level (hazard ratio [HR], 1.1; 95% confidBrain sciencesCerebrospinal Fluid Chloride Is Associated with Disease Activity of Relapsing-Remitting Multiple Sclerosis: A Retrospective Cohort Study.PMC10296568202102010263A20220136Fang XKermode AGLiu ZQiu WLu YFu YLing LLiu CfalseCerebrospinal Fluid Chloride Is Associated with Disease Activity of Relapsing-Remitting Multiple Sclerosis: A Retrospective Cohort Study.<h4>Background</h4>Blood-brain barrier dysfunction in active multiple sclerosis (MS) lesions leads to pathological changes in the cerebrospinal fluid (CSF). This study aimed to investigate the possible association between routine CSF findings, especially CSF chloride, at the time of the first lumbar puncture and the relapse risk and disability progression of relapsing-remitting MS (RRMS).<h4>Methods</h4>This retrospective study included 77 patients with RRMS at the MS Center of our institution from January 2012 to December 2020. The Anderson and Gill (AG) model and Spearman correlation analysis were used to explore predictors of relapse and disability during follow-up.<h4>Results</h4>In the multivariate AG model, patients with elevated CSF chloride level (hazard ratio [HR], 1.1; 95% confid2023-01-01T00:00:00Z2023 Jun2025-04-18T17:27:10.775Z2025-04-07T04:59:02.944ZS-EPMC102965683737140010.3390/brainsci13060924