{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim MK"],"funding":["National Research Foundation of Korea"],"pagination":["10182"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10298908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(12)"],"pubmed_abstract":["Novel genetic and epigenetic factors involved in the development and prognosis of idiopathic pulmonary fibrosis (IPF) have been identified. We previously observed that erythrocyte membrane protein band 4.1-like 3 (<i>EPB41L3</i>) increased in the lung fibroblasts of IPF patients. Thus, we investigated the role of <i>EPB41L3</i> in IPF by comparing the EPB41L3 mRNA and protein expression of lung fibroblast between patients with IPF and controls. We also investigated the regulation of epithelial-mesenchymal transition (EMT) in an epithelial cell line (A549) and fibroblast-to-myofibroblast transition (FMT) in a fibroblast cell line (MRC5) by overexpressing and silencing <i>EPB41L3</i>. EPB41L3 mRNA and protein levels, as measured using RT-PCR, real-time PCR, and Western blot, were significant"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Role of Erythrocyte Membrane Protein Band 4.1-like 3 in Idiopathic Pulmonary Fibrosis."],"pmcid":["PMC10298908"],"funding_grant_id":["NRF-2022R1A2C1010172"],"pubmed_authors":["Lee JU","Lee SJ","Park CS","Kim MK","Chang HS","Park JS"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Erythrocyte Membrane Protein Band 4.1-like 3 in Idiopathic Pulmonary Fibrosis.","description":"Novel genetic and epigenetic factors involved in the development and prognosis of idiopathic pulmonary fibrosis (IPF) have been identified. We previously observed that erythrocyte membrane protein band 4.1-like 3 (<i>EPB41L3</i>) increased in the lung fibroblasts of IPF patients. Thus, we investigated the role of <i>EPB41L3</i> in IPF by comparing the EPB41L3 mRNA and protein expression of lung fibroblast between patients with IPF and controls. We also investigated the regulation of epithelial-mesenchymal transition (EMT) in an epithelial cell line (A549) and fibroblast-to-myofibroblast transition (FMT) in a fibroblast cell line (MRC5) by overexpressing and silencing <i>EPB41L3</i>. EPB41L3 mRNA and protein levels, as measured using RT-PCR, real-time PCR, and Western blot, were significant","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-18T17:26:22.733Z","creation":"2025-04-07T04:57:08.2Z"},"accession":"S-EPMC10298908","cross_references":{"pubmed":["37373330"],"doi":["10.3390/ijms241210182"]}}