{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(6)"],"submitter":["Li X"],"pubmed_abstract":["The reconstruction of blood vessels plays a critical role in the tissue regeneration process. However, existing wound dressings in tissue engineering face challenges due to inadequate revascularization induction and a lack of vascular structure. In this study, we report the modification of mesoporous silica nanospheres (MSNs) with liquid crystal (LC) to enhance bioactivity and biocompatibility in vitro. This LC modification facilitated crucial cellular processes such as the proliferation, migration, spreading, and expression of angiogenesis-related genes and proteins in human umbilical vein endothelial cells (HUVECs). Furthermore, we incorporated LC-modified MSN within a hydrogel matrix to create a multifunctional dressing that combines the biological benefits of LC-MSN with the mechanical"],"journal":["Journal of functional biomaterials"],"pagination":["316"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10299385"],"repository":["biostudies-literature"],"pubmed_title":["Biomimetic Liquid Crystal-Modified Mesoporous Silica-Based Composite Hydrogel for Soft Tissue Repair."],"pmcid":["PMC10299385"],"pubmed_authors":["Li X","Lu H","Wan L","Zhang M","Li R","Zhu T"],"additional_accession":[]},"is_claimable":false,"name":"Biomimetic Liquid Crystal-Modified Mesoporous Silica-Based Composite Hydrogel for Soft Tissue Repair.","description":"The reconstruction of blood vessels plays a critical role in the tissue regeneration process. However, existing wound dressings in tissue engineering face challenges due to inadequate revascularization induction and a lack of vascular structure. In this study, we report the modification of mesoporous silica nanospheres (MSNs) with liquid crystal (LC) to enhance bioactivity and biocompatibility in vitro. This LC modification facilitated crucial cellular processes such as the proliferation, migration, spreading, and expression of angiogenesis-related genes and proteins in human umbilical vein endothelial cells (HUVECs). Furthermore, we incorporated LC-modified MSN within a hydrogel matrix to create a multifunctional dressing that combines the biological benefits of LC-MSN with the mechanical","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-26T04:50:33.504Z","creation":"2025-04-06T11:14:25.513Z"},"accession":"S-EPMC10299385","cross_references":{"pubmed":["37367280"],"doi":["10.3390/jfb14060316"]}}