{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(12)"],"submitter":["Kanda Y"],"pubmed_abstract":["Crops experience herbivory by arthropods and microbial infections. In the interaction between plants and chewing herbivores, lepidopteran larval oral secretions (OS) and plant-derived damage-associated molecular patterns (DAMPs) trigger plant defense responses. However, the mechanisms underlying anti-herbivore defense, especially in monocots, have not been elucidated. The receptor-like cytoplasmic kinase Broad-Spectrum Resistance 1 (BSR1) of <i>Oryza sativa</i> L. (rice) mediates cytoplasmic defense signaling in response to microbial pathogens and enhances disease resistance when overexpressed. Here, we investigated whether BSR1 contributes to anti-herbivore defense responses. <i>BSR1</i> knockout suppressed rice responses triggered by OS from the chewing herbivore <i>Mythimna loreyi</i> Duponchel (Lepidoptera: Noctuidae) and peptidic DAMPs OsPeps, including the activation of genes required for biosynthesis of diterpenoid phytoalexins (DPs). <i>BSR1</i>-overexpressing rice plants exhibited hyperactivation of DP accumulation and ethylene signaling after treatment with simulated herbivory and acquired enhanced resistance to larval feeding. As the biological significance of herbivory-induced accumulation of rice DPs remains unexplained, their physiological activities in <i>M. loreyi</i> were analyzed. The addition of momilactone B, a rice DP, to the artificial diet suppressed the growth of <i>M. loreyi</i> larvae. Altogether, this study revealed that BSR1 and herbivory-induced rice DPs are involved in the defense against chewing insects, in addition to pathogens."],"journal":["International journal of molecular sciences"],"pagination":["10395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10299516"],"repository":["biostudies-literature"],"pubmed_title":["BSR1, a Rice Receptor-like Cytoplasmic Kinase, Positively Regulates Defense Responses to Herbivory."],"pmcid":["PMC10299516"],"pubmed_authors":["Mori M","Mujiono K","Maeda S","Okada K","Galis I","Kanda Y","Shinya T","Tomita K","Kamakura T","Hojo Y"],"additional_accession":[]},"is_claimable":false,"name":"BSR1, a Rice Receptor-like Cytoplasmic Kinase, Positively Regulates Defense Responses to Herbivory.","description":"Crops experience herbivory by arthropods and microbial infections. In the interaction between plants and chewing herbivores, lepidopteran larval oral secretions (OS) and plant-derived damage-associated molecular patterns (DAMPs) trigger plant defense responses. However, the mechanisms underlying anti-herbivore defense, especially in monocots, have not been elucidated. The receptor-like cytoplasmic kinase Broad-Spectrum Resistance 1 (BSR1) of <i>Oryza sativa</i> L. (rice) mediates cytoplasmic defense signaling in response to microbial pathogens and enhances disease resistance when overexpressed. Here, we investigated whether BSR1 contributes to anti-herbivore defense responses. <i>BSR1</i> knockout suppressed rice responses triggered by OS from the chewing herbivore <i>Mythimna loreyi</i> Duponchel (Lepidoptera: Noctuidae) and peptidic DAMPs OsPeps, including the activation of genes required for biosynthesis of diterpenoid phytoalexins (DPs). <i>BSR1</i>-overexpressing rice plants exhibited hyperactivation of DP accumulation and ethylene signaling after treatment with simulated herbivory and acquired enhanced resistance to larval feeding. As the biological significance of herbivory-induced accumulation of rice DPs remains unexplained, their physiological activities in <i>M. loreyi</i> were analyzed. The addition of momilactone B, a rice DP, to the artificial diet suppressed the growth of <i>M. loreyi</i> larvae. Altogether, this study revealed that BSR1 and herbivory-induced rice DPs are involved in the defense against chewing insects, in addition to pathogens.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T12:11:41.259Z","creation":"2025-04-04T12:11:41.259Z"},"accession":"S-EPMC10299516","cross_references":{"pubmed":["37373546"],"doi":["10.3390/ijms241210395"]}}