{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aksenov AV"],"funding":["Russian Science Foundation"],"pagination":["10213"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10299564"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(12)"],"pubmed_abstract":["The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry."],"journal":["International journal of molecular sciences"],"pubmed_title":["A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams."],"pmcid":["PMC10299564"],"funding_grant_id":["21-73-10029"],"pubmed_authors":["Aksenov DA","Kurenkov IA","Leontiev AV","Aksenov AV","Aksenov NA"],"additional_accession":[]},"is_claimable":false,"name":"A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams.","description":"The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-18T17:25:49.908Z","creation":"2025-04-07T04:56:41.662Z"},"accession":"S-EPMC10299564","cross_references":{"pubmed":["37373361"],"doi":["10.3390/ijms241210213"]}}