biostudies-literatureAksenov AVRussian Science Foundation10213https://www.ebi.ac.uk/biostudies/studies/S-EPMC10299564biostudies-literatureUnknown24(12)The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.International journal of molecular sciencesA New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams.PMC1029956421-73-10029Aksenov DAKurenkov IALeontiev AVAksenov AVAksenov NAfalseA New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams.The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.2023-01-01T00:00:00Z2023 Jun2025-04-18T17:25:49.908Z2025-04-07T04:56:41.662ZS-EPMC102995643737336110.3390/ijms241210213