{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(6)"],"submitter":["Lanni A"],"pubmed_abstract":["The lungs of tuberculosis (TB) patients contain a spectrum of granulomatous lesions, ranging from solid and well-vascularized cellular granulomas to avascular caseous granulomas. In solid granulomas, current therapy kills actively replicating (AR) intracellular bacilli, while in low-vascularized caseous granulomas the low-oxygen tension stimulates aerobic and microaerophilic AR bacilli to transit into non-replicating (NR), drug-tolerant and extracellular stages. These stages, which do not have genetic mutations and are often referred to as persisters, are difficult to eradicate due to low drug penetration inside the caseum and mycobacterial cell walls. The sputum of TB patients also contains viable bacilli called differentially detectable (DD) cells that, unlike persisters, grow in liquid,"],"journal":["Microorganisms"],"pagination":["1511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10301435"],"repository":["biostudies-literature"],"pubmed_title":["Eradication of Drug-Tolerant <i>Mycobacterium tuberculosis</i> 2022: Where We Stand."],"pmcid":["PMC10301435"],"pubmed_authors":["Iacobino A","Lanni A","Giannoni F","Fattorini L"],"additional_accession":[]},"is_claimable":false,"name":"Eradication of Drug-Tolerant <i>Mycobacterium tuberculosis</i> 2022: Where We Stand.","description":"The lungs of tuberculosis (TB) patients contain a spectrum of granulomatous lesions, ranging from solid and well-vascularized cellular granulomas to avascular caseous granulomas. In solid granulomas, current therapy kills actively replicating (AR) intracellular bacilli, while in low-vascularized caseous granulomas the low-oxygen tension stimulates aerobic and microaerophilic AR bacilli to transit into non-replicating (NR), drug-tolerant and extracellular stages. These stages, which do not have genetic mutations and are often referred to as persisters, are difficult to eradicate due to low drug penetration inside the caseum and mycobacterial cell walls. The sputum of TB patients also contains viable bacilli called differentially detectable (DD) cells that, unlike persisters, grow in liquid,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-26T21:16:29.553Z","creation":"2025-04-06T16:42:07.501Z"},"accession":"S-EPMC10301435","cross_references":{"pubmed":["37375013"],"doi":["10.3390/microorganisms11061511"]}}