{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Greco F"],"funding":["Istituto Pasteur—Fondazione Cenci Bolognetti to Valerio Fulci","Ministry of Health","Ministry of Health “Ricerca Corrente 2023”","istituto Pasteur Italia - Fondazione Cenci Bolognetti"],"pagination":["33"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10301948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Virus-encoded microRNAs were first reported in the Epstein-Barr virus in 2004. Subsequently, a few hundred viral miRNAs have been identified, mainly in DNA viruses belonging to the <i>herpesviridae</i> family. To date, only 30 viral miRNAs encoded by RNA viruses are reported by miRBase. Since the outbreak of the SARS-CoV-2 pandemic, several studies have predicted and, in some cases, experimentally validated miRNAs originating from the positive strand of the SARS-CoV-2 genome. By integrating NGS data analysis and qRT-PCR approaches, we found that SARS-CoV-2 also encodes for a viral miRNA arising from the minus (antisense) strand of the viral genome, in the region encoding for ORF1ab, herein referred to as SARS-CoV-2-miR-AS1. Our data show that the expression of this microRNA increases in a "],"journal":["Non-coding RNA"],"pubmed_title":["A microRNA Arising from the Negative Strand of SARS-CoV-2 Genome Targets FOS to Reduce AP-1 Activity."],"pmcid":["PMC10301948"],"funding_grant_id":["Ricerca Corrente 2023","Call “under 45”—2020","under 45 2020"],"pubmed_authors":["Ciccosanti F","Di Rienzo M","Fimia GM","Fulci V","Lorefice E","Laudadio I","Maggi F","Carissimi C","Greco F","Meschi S","Colavita F"],"additional_accession":[]},"is_claimable":false,"name":"A microRNA Arising from the Negative Strand of SARS-CoV-2 Genome Targets FOS to Reduce AP-1 Activity.","description":"Virus-encoded microRNAs were first reported in the Epstein-Barr virus in 2004. Subsequently, a few hundred viral miRNAs have been identified, mainly in DNA viruses belonging to the <i>herpesviridae</i> family. To date, only 30 viral miRNAs encoded by RNA viruses are reported by miRBase. Since the outbreak of the SARS-CoV-2 pandemic, several studies have predicted and, in some cases, experimentally validated miRNAs originating from the positive strand of the SARS-CoV-2 genome. By integrating NGS data analysis and qRT-PCR approaches, we found that SARS-CoV-2 also encodes for a viral miRNA arising from the minus (antisense) strand of the viral genome, in the region encoding for ORF1ab, herein referred to as SARS-CoV-2-miR-AS1. Our data show that the expression of this microRNA increases in a ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-04-08T14:08:47.762Z","creation":"2025-04-04T20:28:32.951Z"},"accession":"S-EPMC10301948","cross_references":{"pubmed":["37368333"],"doi":["10.3390/ncrna9030033"]}}