{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(2)"],"submitter":["Jeusset L"],"pubmed_abstract":["High throughput sequencing of adaptive immune receptor repertoire (AIRR-seq) has provided numerous human immunoglobulin (IG) sequences allowing specific B cell receptor (BCR) studies such as the antigen-driven evolution of antibodies (soluble forms of the membrane-bound IG part of the BCR). AIRR-seq data allows researchers to examine intraclonal differences caused primarily by somatic hypermutations in IG genes and affinity maturation. Exploring this essential adaptive immunity process could help elucidate the generation of antibodies with high affinity or broadly neutralizing activities. Retracing their evolutionary history could also clarify how vaccines or pathogen exposition drive the humoral immune response, and unravel the clonal architecture of B cell tumors. Computational methods a"],"journal":["NAR genomics and bioinformatics"],"pagination":["lqad064"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10304752"],"repository":["biostudies-literature"],"pubmed_title":["ViCloD, an interactive web tool for visualizing B cell repertoires and analyzing intraclonal diversities: application to human B-cell tumors."],"pmcid":["PMC10304752"],"pubmed_authors":["Davi F","Bernardes JS","Abdollahi N","Armand M","De Septenville AL","Verny T","Jeusset L"],"additional_accession":[]},"is_claimable":false,"name":"ViCloD, an interactive web tool for visualizing B cell repertoires and analyzing intraclonal diversities: application to human B-cell tumors.","description":"High throughput sequencing of adaptive immune receptor repertoire (AIRR-seq) has provided numerous human immunoglobulin (IG) sequences allowing specific B cell receptor (BCR) studies such as the antigen-driven evolution of antibodies (soluble forms of the membrane-bound IG part of the BCR). AIRR-seq data allows researchers to examine intraclonal differences caused primarily by somatic hypermutations in IG genes and affinity maturation. Exploring this essential adaptive immunity process could help elucidate the generation of antibodies with high affinity or broadly neutralizing activities. Retracing their evolutionary history could also clarify how vaccines or pathogen exposition drive the humoral immune response, and unravel the clonal architecture of B cell tumors. Computational methods a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-05T12:40:08.589Z","creation":"2025-04-05T12:40:08.589Z"},"accession":"S-EPMC10304752","cross_references":{"pubmed":["37388820"],"doi":["10.1093/nargab/lqad064"]}}