{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(6)"],"submitter":["Liu L"],"pubmed_abstract":["<h4>Background</h4>Studying the mechanism of action of LncRNAs in lung adenocarcinoma (LUAD) is of great importance for an in-depth understanding of the molecular mechanism of lung adeno carcinogenesis and development.<h4>Objective</h4>The aim is to identify a long non-coding RNA LINC01117 that is specifically and highly expressed in LUAD cells and to investigate its biological functions and molecular mechanisms in LUAD cells, providing a new potential target for targeting LUAD therapy.<h4>Methods</h4>This study used publicly available data downloaded from The Cancer Genome Atlas (TCGA) database. Construction of siRNA and overexpression plasmid-packed lentiviral constructs were used to knock down and increase the expression of LINC01117 in LUAD cells. The effect of LINC01117 on LUAD cell m"],"journal":["PloS one"],"pagination":["e0287926"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10310029"],"repository":["biostudies-literature"],"pubmed_title":["LINC01117 inhibits invasion and migration of lung adenocarcinoma through influencing EMT process."],"pmcid":["PMC10310029"],"pubmed_authors":["Ren W","Xu K","Liu L","Zhou Y","Du L"],"additional_accession":[]},"is_claimable":false,"name":"LINC01117 inhibits invasion and migration of lung adenocarcinoma through influencing EMT process.","description":"<h4>Background</h4>Studying the mechanism of action of LncRNAs in lung adenocarcinoma (LUAD) is of great importance for an in-depth understanding of the molecular mechanism of lung adeno carcinogenesis and development.<h4>Objective</h4>The aim is to identify a long non-coding RNA LINC01117 that is specifically and highly expressed in LUAD cells and to investigate its biological functions and molecular mechanisms in LUAD cells, providing a new potential target for targeting LUAD therapy.<h4>Methods</h4>This study used publicly available data downloaded from The Cancer Genome Atlas (TCGA) database. Construction of siRNA and overexpression plasmid-packed lentiviral constructs were used to knock down and increase the expression of LINC01117 in LUAD cells. The effect of LINC01117 on LUAD cell m","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T14:08:18.289Z","creation":"2025-04-04T14:08:18.289Z"},"accession":"S-EPMC10310029","cross_references":{"pubmed":["37384755"],"doi":["10.1371/journal.pone.0287926"]}}