biostudies-literatureUnknown18(6)Liu L<h4>Background</h4>Studying the mechanism of action of LncRNAs in lung adenocarcinoma (LUAD) is of great importance for an in-depth understanding of the molecular mechanism of lung adeno carcinogenesis and development.<h4>Objective</h4>The aim is to identify a long non-coding RNA LINC01117 that is specifically and highly expressed in LUAD cells and to investigate its biological functions and molecular mechanisms in LUAD cells, providing a new potential target for targeting LUAD therapy.<h4>Methods</h4>This study used publicly available data downloaded from The Cancer Genome Atlas (TCGA) database. Construction of siRNA and overexpression plasmid-packed lentiviral constructs were used to knock down and increase the expression of LINC01117 in LUAD cells. The effect of LINC01117 on LUAD cell mPloS onee0287926https://www.ebi.ac.uk/biostudies/studies/S-EPMC10310029biostudies-literatureLINC01117 inhibits invasion and migration of lung adenocarcinoma through influencing EMT process.PMC10310029Ren WXu KLiu LZhou YDu LfalseLINC01117 inhibits invasion and migration of lung adenocarcinoma through influencing EMT process.<h4>Background</h4>Studying the mechanism of action of LncRNAs in lung adenocarcinoma (LUAD) is of great importance for an in-depth understanding of the molecular mechanism of lung adeno carcinogenesis and development.<h4>Objective</h4>The aim is to identify a long non-coding RNA LINC01117 that is specifically and highly expressed in LUAD cells and to investigate its biological functions and molecular mechanisms in LUAD cells, providing a new potential target for targeting LUAD therapy.<h4>Methods</h4>This study used publicly available data downloaded from The Cancer Genome Atlas (TCGA) database. Construction of siRNA and overexpression plasmid-packed lentiviral constructs were used to knock down and increase the expression of LINC01117 in LUAD cells. The effect of LINC01117 on LUAD cell m2023-01-01T00:00:00Z20232025-04-04T14:08:18.289Z2025-04-04T14:08:18.289ZS-EPMC103100293738475510.1371/journal.pone.0287926