biostudies-literatureLi TNCI NIH HHSNIGMS NIH HHS959-964https://www.ebi.ac.uk/biostudies/studies/S-EPMC10312138biostudies-literatureUnknown9(8)Brillouin microscopy is an emerging label-free imaging technique used to assess local viscoelastic properties. Quantum-enhanced stimulated Brillouin scattering is demonstrated using low power continuous-wave lasers at 795 nm. A signal-to-noise ratio enhancement of 3.4 dB is reported by using two-mode intensity-difference squeezed light generated with the four-wave mixing process in atomic rubidium vapor. The low optical power and the excitation wavelengths in the water transparency window have the potential to provide a powerful bio-imaging technique for probing mechanical properties of biological samples prone to phototoxicity and thermal effects. The performance enhancement affordable through the use of quantum light may pave the way for significantly improved sensitivity that cannot be OpticaQuantum-enhanced stimulated Brillouin scattering spectroscopy and imaging.PMC10312138R01 GM127696R21 CA269099R21 GM142107Liu XLi TLi FAgarwal GSYakovlev VVfalseQuantum-enhanced stimulated Brillouin scattering spectroscopy and imaging.Brillouin microscopy is an emerging label-free imaging technique used to assess local viscoelastic properties. Quantum-enhanced stimulated Brillouin scattering is demonstrated using low power continuous-wave lasers at 795 nm. A signal-to-noise ratio enhancement of 3.4 dB is reported by using two-mode intensity-difference squeezed light generated with the four-wave mixing process in atomic rubidium vapor. The low optical power and the excitation wavelengths in the water transparency window have the potential to provide a powerful bio-imaging technique for probing mechanical properties of biological samples prone to phototoxicity and thermal effects. The performance enhancement affordable through the use of quantum light may pave the way for significantly improved sensitivity that cannot be 2022-01-01T00:00:00Z2022 Aug2025-04-19T07:30:39.234Z2025-04-19T07:30:39.234ZS-EPMC103121383739889510.1364/optica.467635