{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Jeong Y"],"funding":["NEI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS","NIH HHS"],"pubmed_abstract":["We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large-effect glaucoma genes and axonal damage occurs at the optic nerve head in glaucoma, here we explored whether OPTN mutations perturb transmitophagy. Live-imaging of <i>Xenopus laevis</i> optic nerves revealed that diverse human mutant but not wildtype OPTN increase stationary mitochondria and mitophagy machinery and their colocalization within, and in the case of the glaucoma-associated OPTN mutations also outside of, RGC axons. These extra-axonal mitochondria are degraded by astrocytes. Our studies support the v"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.05.26.542507"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10312487"],"repository":["biostudies-literature"],"pubmed_title":["Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve."],"pmcid":["PMC10312487"],"funding_grant_id":["S10 OD021784","R01 EY026471","R01 GM082949","U24 NS120055","R01 EY029087","P30 EY012576"],"pubmed_authors":["Jeong Y","Deshpande V","Ellisman MH","Marsh-Armstrong N","Muscarella AM","Kim KY","Davis CO"],"additional_accession":[]},"is_claimable":false,"name":"Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve.","description":"We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large-effect glaucoma genes and axonal damage occurs at the optic nerve head in glaucoma, here we explored whether OPTN mutations perturb transmitophagy. Live-imaging of <i>Xenopus laevis</i> optic nerves revealed that diverse human mutant but not wildtype OPTN increase stationary mitochondria and mitophagy machinery and their colocalization within, and in the case of the glaucoma-associated OPTN mutations also outside of, RGC axons. These extra-axonal mitochondria are degraded by astrocytes. Our studies support the v","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-04-19T03:23:50.579Z","creation":"2026-04-19T03:13:17.728Z"},"accession":"S-EPMC10312487","cross_references":{"pubmed":["37398269"],"doi":["10.1101/2023.05.26.542507"]}}