{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Norris AC"],"funding":["BLRD VA","NEI NIH HHS","NCRR NIH HHS","NIDDK NIH HHS","NIA NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide across cell membranes, and these lipids or their metabolites play important roles in signal transduction pathways regulating metabolism. However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific <i>Atp10A</i> knockout mice and show that <i>Atp10A</i><sup>-/-</sup> mice fed a high-fat diet did not gain excess weight relative to wild-type littermates. However, <i>Atp10A</i><sup>-/-</sup> mice displayed female-specific dyslipidemia characterized by elevated plasma triglycerides, free fatty acids and "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.06.16.545392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10312798"],"repository":["biostudies-literature"],"pubmed_title":["Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice."],"pmcid":["PMC10312798"],"funding_grant_id":["OT2 OD030544","U2C DK119886","K01 AG077038","U24 DK059637","P30 DK058404","R01 DK109102","R35 GM144123","P30 EY008126","T35 DK007383","S10 OD021630","I01 BX002223","P30 DK020593","P30 CA068485","S10 RR028101","R01 HL144846"],"pubmed_authors":["Norris AC","Gibson-Corley KN","Yazlovitskaya EM","Zhu L","May JC","Rose BS","McLean JA","Graham TR","Stafford JM"],"additional_accession":[]},"is_claimable":false,"name":"Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.","description":"Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide across cell membranes, and these lipids or their metabolites play important roles in signal transduction pathways regulating metabolism. However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific <i>Atp10A</i> knockout mice and show that <i>Atp10A</i><sup>-/-</sup> mice fed a high-fat diet did not gain excess weight relative to wild-type littermates. However, <i>Atp10A</i><sup>-/-</sup> mice displayed female-specific dyslipidemia characterized by elevated plasma triglycerides, free fatty acids and ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-04-07T13:33:28.14Z","creation":"2024-11-21T11:05:07.673Z"},"accession":"S-EPMC10312798","cross_references":{"pubmed":["37398141"],"doi":["10.1101/2023.06.16.545392"]}}