{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morton JT"],"funding":["Eunice Kennedy Shriver National Institute of Child Health and Human Development","European Research Council","Israel Science Foundation","National Natural Science Foundation of China","Wellcome Trust"],"pagination":["1208-1217"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10322709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(7)"],"pubmed_abstract":["Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited reproducibility across studies. In this study, we developed a Bayesian differential ranking algorithm to identify ASD-associated molecular and taxa profiles across 10 cross-sectional microbiome datasets and 15 other datasets, including dietary patterns, metabolomics, cytokine profiles and human brain gene expression profiles. We found a functional architecture along the GBA that correlates with heterogeneity of ASD phenotypes, and it is characterized by ASD-associated amino acid, carbohydrate and lipid profiles predominantly encoded by microbial species in t"],"journal":["Nature neuroscience"],"pubmed_title":["Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles."],"pmcid":["PMC10322709"],"funding_grant_id":["WT206194","101001355","82071733)","818/17"],"pubmed_authors":["McDonald D","Danilenko VN","Elliott E","Frankiensztajn LM","Lawley TD","Cardenas P","Donovan SM","Jiang Y","Wang M","Noto A","Shao Y","Koren O","Morton JT","Balaban M","Averina OV","Bonneau R","Mazmanian SK","Jin DM","David M","Jacquemont S","Zurita MF","Needham BD","Mills RH","Frank DN","Wall DP","Li E","Cantrell K","Taroncher-Oldenburg G","Xavier RJ","Carmel J","Rahman G","Martin-Brevet S","Zhou W","Gilbert JA","Fanos V","Knight R","Kovtun AS","Carpenter B","Mussap M","Baldeon ME","Berding K","Zhu Q","Gonzalez A"],"additional_accession":[]},"is_claimable":false,"name":"Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles.","description":"Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited reproducibility across studies. In this study, we developed a Bayesian differential ranking algorithm to identify ASD-associated molecular and taxa profiles across 10 cross-sectional microbiome datasets and 15 other datasets, including dietary patterns, metabolomics, cytokine profiles and human brain gene expression profiles. We found a functional architecture along the GBA that correlates with heterogeneity of ASD phenotypes, and it is characterized by ASD-associated amino acid, carbohydrate and lipid profiles predominantly encoded by microbial species in t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-06-01T00:14:31.669Z","creation":"2025-06-01T00:14:31.669Z"},"accession":"S-EPMC10322709","cross_references":{"pubmed":["37365313"],"doi":["10.1038/s41593-023-01361-0"]}}