{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Lin Z"],"pubmed_abstract":["<h4>Background</h4>Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma with a poor prognosis. We aimed to evaluate the prognostic impact of circulating NK cells in PCNSL.<h4>Materials and methods</h4>Patients diagnosed with PCNSL who were treated at our institution between December 2018 and December 2019 were retrospectively screened. Patient variables including age, sex, Karnofsky performance status, diagnostic methods, location of lesions, lactate dehydrogenase, cerebrospinal fluids (CSF), and vitreous fluids involvement or not were documented. NK cell count and NK cell proportion (NK cell count/lymphocyte count) in the peripheral blood were evaluated by flow cytometry. Some patients underwent two consecutive NK cell tests before and three wee"],"journal":["Frontiers in immunology"],"pagination":["1191033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10326164"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic impact of peripheral natural killer cells in primary central nervous system lymphoma."],"pmcid":["PMC10326164"],"pubmed_authors":["Kang H","Ma Y","Ma J","Li Q","Zhang M","Lin Z","Xia R","Chen B"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic impact of peripheral natural killer cells in primary central nervous system lymphoma.","description":"<h4>Background</h4>Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma with a poor prognosis. We aimed to evaluate the prognostic impact of circulating NK cells in PCNSL.<h4>Materials and methods</h4>Patients diagnosed with PCNSL who were treated at our institution between December 2018 and December 2019 were retrospectively screened. Patient variables including age, sex, Karnofsky performance status, diagnostic methods, location of lesions, lactate dehydrogenase, cerebrospinal fluids (CSF), and vitreous fluids involvement or not were documented. NK cell count and NK cell proportion (NK cell count/lymphocyte count) in the peripheral blood were evaluated by flow cytometry. Some patients underwent two consecutive NK cell tests before and three wee","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-20T03:46:51.907Z","creation":"2025-04-20T03:46:51.907Z"},"accession":"S-EPMC10326164","cross_references":{"pubmed":["37426647"],"doi":["10.3389/fimmu.2023.1191033"]}}